CRGF_BOVIN
ID CRGF_BOVIN Reviewed; 174 AA.
AC P23005;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Gamma-crystallin F;
DE AltName: Full=Gamma-F-crystallin;
DE AltName: Full=Gamma-crystallin IVA;
GN Name=CRYGF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX PubMed=2738925; DOI=10.1016/0022-2836(89)90452-x;
RA White H.E., Driessen H.P.C., Slingsby C., Moss D.S., Lindley P.F.;
RT "Packing interactions in the eye-lens. Structural analysis, internal
RT symmetry and lattice interactions of bovine gamma IVa-crystallin.";
RL J. Mol. Biol. 207:217-235(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE, AND X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX PubMed=9367641; DOI=10.1006/exer.1997.0368;
RA Norledge B.V., Hay R.E., Bateman O.A., Slingsby C., Driessen H.P.C.;
RT "Towards a molecular understanding of phase separation in the lens: a
RT comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE
RT and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD.";
RL Exp. Eye Res. 65:609-630(1997).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_001193748.1; NM_001206819.1.
DR PDB; 1A45; X-ray; 2.30 A; A=2-174.
DR PDB; 1M8U; X-ray; 1.65 A; A=2-174.
DR PDBsum; 1A45; -.
DR PDBsum; 1M8U; -.
DR AlphaFoldDB; P23005; -.
DR PCDDB; P23005; -.
DR SMR; P23005; -.
DR STRING; 9913.ENSBTAP00000018740; -.
DR PaxDb; P23005; -.
DR Ensembl; ENSBTAT00000018740; ENSBTAP00000018740; ENSBTAG00000052197.
DR GeneID; 616092; -.
DR KEGG; bta:616092; -.
DR VEuPathDB; HostDB:ENSBTAG00000052197; -.
DR eggNOG; ENOG502RXJY; Eukaryota.
DR GeneTree; ENSGT00940000158720; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P23005; -.
DR OMA; GCWFLRR; -.
DR OrthoDB; 1220704at2759; -.
DR EvolutionaryTrace; P23005; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000052197; Expressed in oocyte and 3 other tissues.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Gamma-crystallin F"
FT /id="PRO_0000057584"
FT DOMAIN 2..40
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 41..83
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 88..128
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 129..171
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 84..87
FT /note="Connecting peptide"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:1M8U"
FT TURN 10..12
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 13..19
FT /evidence="ECO:0007829|PDB:1M8U"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 35..41
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 43..48
FT /evidence="ECO:0007829|PDB:1M8U"
FT HELIX 49..51
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 60..63
FT /evidence="ECO:0007829|PDB:1M8U"
FT HELIX 66..69
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 78..81
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 89..95
FT /evidence="ECO:0007829|PDB:1M8U"
FT TURN 96..98
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 99..105
FT /evidence="ECO:0007829|PDB:1M8U"
FT TURN 112..114
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 115..117
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 123..129
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 131..136
FT /evidence="ECO:0007829|PDB:1M8U"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 140..146
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 148..153
FT /evidence="ECO:0007829|PDB:1M8U"
FT HELIX 154..157
FT /evidence="ECO:0007829|PDB:1M8U"
FT STRAND 166..169
FT /evidence="ECO:0007829|PDB:1M8U"
SQ SEQUENCE 174 AA; 21086 MW; 1ED266259EB6DC70 CRC64;
MGKITFYEDR GFQGRHYECS SDHSNLQPYF SRCNSIRVDS GCWMLYEQPN FQGPQYFLRR
GDYPDYQQWM GLNDSIRSCR LIPHTGSHRL RIYEREDYRG QMVEITEDCS SLHDRFHFSE
IHSFNVLEGW WVLYEMTNYR GRQYLLRPGD YRRYHDWGAT NARVGSLRRA VDFY