位置:首页 > 蛋白库 > CRGF_BOVIN
CRGF_BOVIN
ID   CRGF_BOVIN              Reviewed;         174 AA.
AC   P23005;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Gamma-crystallin F;
DE   AltName: Full=Gamma-F-crystallin;
DE   AltName: Full=Gamma-crystallin IVA;
GN   Name=CRYGF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX   PubMed=2738925; DOI=10.1016/0022-2836(89)90452-x;
RA   White H.E., Driessen H.P.C., Slingsby C., Moss D.S., Lindley P.F.;
RT   "Packing interactions in the eye-lens. Structural analysis, internal
RT   symmetry and lattice interactions of bovine gamma IVa-crystallin.";
RL   J. Mol. Biol. 207:217-235(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE, AND X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX   PubMed=9367641; DOI=10.1006/exer.1997.0368;
RA   Norledge B.V., Hay R.E., Bateman O.A., Slingsby C., Driessen H.P.C.;
RT   "Towards a molecular understanding of phase separation in the lens: a
RT   comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE
RT   and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD.";
RL   Exp. Eye Res. 65:609-630(1997).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; NP_001193748.1; NM_001206819.1.
DR   PDB; 1A45; X-ray; 2.30 A; A=2-174.
DR   PDB; 1M8U; X-ray; 1.65 A; A=2-174.
DR   PDBsum; 1A45; -.
DR   PDBsum; 1M8U; -.
DR   AlphaFoldDB; P23005; -.
DR   PCDDB; P23005; -.
DR   SMR; P23005; -.
DR   STRING; 9913.ENSBTAP00000018740; -.
DR   PaxDb; P23005; -.
DR   Ensembl; ENSBTAT00000018740; ENSBTAP00000018740; ENSBTAG00000052197.
DR   GeneID; 616092; -.
DR   KEGG; bta:616092; -.
DR   VEuPathDB; HostDB:ENSBTAG00000052197; -.
DR   eggNOG; ENOG502RXJY; Eukaryota.
DR   GeneTree; ENSGT00940000158720; -.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; P23005; -.
DR   OMA; GCWFLRR; -.
DR   OrthoDB; 1220704at2759; -.
DR   EvolutionaryTrace; P23005; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000052197; Expressed in oocyte and 3 other tissues.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   1: Evidence at protein level;
KW   3D-structure; Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..174
FT                   /note="Gamma-crystallin F"
FT                   /id="PRO_0000057584"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..171
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..87
FT                   /note="Connecting peptide"
FT   STRAND          3..9
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   TURN            10..12
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          13..19
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   TURN            27..29
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          35..41
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          43..48
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   HELIX           49..51
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          53..58
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          60..63
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   HELIX           66..69
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          72..74
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          78..81
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          89..95
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   TURN            96..98
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          99..105
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   TURN            112..114
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          115..117
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          123..129
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          131..136
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   TURN            137..139
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          140..146
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          148..153
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   HELIX           154..157
FT                   /evidence="ECO:0007829|PDB:1M8U"
FT   STRAND          166..169
FT                   /evidence="ECO:0007829|PDB:1M8U"
SQ   SEQUENCE   174 AA;  21086 MW;  1ED266259EB6DC70 CRC64;
     MGKITFYEDR GFQGRHYECS SDHSNLQPYF SRCNSIRVDS GCWMLYEQPN FQGPQYFLRR
     GDYPDYQQWM GLNDSIRSCR LIPHTGSHRL RIYEREDYRG QMVEITEDCS SLHDRFHFSE
     IHSFNVLEGW WVLYEMTNYR GRQYLLRPGD YRRYHDWGAT NARVGSLRRA VDFY
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024