ID   CRGM1_CHIID             Reviewed;         175 AA.
AC   P48648;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Gamma-crystallin M1;
DE            Short=Gamma-M1;
GN   Name=GM1;
OS   Chiloscyllium indicum (Slender bamboo shark) (Chiloscyllium colax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC   Chiloscyllium.
OX   NCBI_TaxID=443761;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RA   Chuang M.-H., Pan F.-M., Chiou S.-H.;
RL   Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; X79228; CAA55810.1; -; mRNA.
DR   PIR; S45014; S45014.
DR   AlphaFoldDB; P48648; -.
DR   SMR; P48648; -.
DR   PRIDE; P48648; -.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..175
FT                   /note="Gamma-crystallin M1"
FT                   /id="PRO_0000057577"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..86
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          89..121
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          130..172
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
SQ   SEQUENCE   175 AA;  21410 MW;  B0CB3A14D3E14B59 CRC64;
     MGKIIFYEDR NFQGRSYECM SDCSDITTYM SRCQSCRVES GCFMVYERPN FMGMQFFLRR
     GEYHDMQRMM SMGMMFDSIR SCRYPYRAFR MRIYEREYFG GQMSELMGDC DSIMDRFRMS
     DCMYCHVMDG HWLMYEQAHY RGKMMYLRPG EYRSFRDMGM SGMRFMSMRR ITDMC