ID   CRGM1_CYPCA             Reviewed;         178 AA.
AC   P10043;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Gamma-crystallin M1;
DE            Short=Gamma-M1;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Lens;
RX   PubMed=1840497; DOI=10.1016/0167-4781(91)90114-2;
RA   Chang T., Lin C.L., Chang W.C., Chen P.H.;
RT   "Gamma-crystallin genes in carp: cloning and characterization.";
RL   Biochim. Biophys. Acta 1090:261-264(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=3191133; DOI=10.1016/0167-4781(88)90044-9;
RA   Chang T., Jiang Y.-J., Chiou S.-H., Chang W.-C.;
RT   "Carp gamma-crystallins with high methionine content: cloning and
RT   sequencing of the complementary DNA.";
RL   Biochim. Biophys. Acta 951:226-229(1988).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; X55945; CAA39413.1; -; Genomic_DNA.
DR   EMBL; X12902; CAA31387.1; -; mRNA.
DR   PIR; JS0061; CYCAG1.
DR   PIR; S18459; S18459.
DR   AlphaFoldDB; P10043; -.
DR   SMR; P10043; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..178
FT                   /note="Gamma-crystallin M1"
FT                   /id="PRO_0000057574"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..86
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          92..132
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          133..175
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          87..91
FT                   /note="Connecting peptide"
FT   CONFLICT        8
FT                   /note="D -> E (in Ref. 2; CAA31387)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75
FT                   /note="I -> M (in Ref. 2; CAA31387)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        101
FT                   /note="N -> T (in Ref. 2; CAA31387)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        177
FT                   /note="I -> M (in Ref. 2; CAA31387)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   178 AA;  21845 MW;  48618E54BFD7DA2D CRC64;
     MGKIIFYDDR NFQGRSYDCM SDCSDISSYL SRVGSIRVES GCFMVYERNS YMGNQFFLRR
     GEYHDMQRMM SMGMIFDTIR SCRMIPPYRG SYRMRIYERD NFGGQMHEVM DDCDNIMERY
     RMSDWQSCHV MDGHWLFYEQ PHYRGRMWYF RPGEYRSFRD MGYSNMRFMS MRRITDIC