ID   CRGM2_CYPCA             Reviewed;         173 AA.
AC   P10044;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Gamma-crystallin M2;
DE            Short=Gamma-M2;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lens;
RX   PubMed=3191133; DOI=10.1016/0167-4781(88)90044-9;
RA   Chang T., Jiang Y.-J., Chiou S.-H., Chang W.-C.;
RT   "Carp gamma-crystallins with high methionine content: cloning and
RT   sequencing of the complementary DNA.";
RL   Biochim. Biophys. Acta 951:226-229(1988).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; X12903; CAA31388.1; -; mRNA.
DR   PIR; JS0062; CYCAG2.
DR   AlphaFoldDB; P10044; -.
DR   SMR; P10044; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..173
FT                   /note="Gamma-crystallin M2"
FT                   /id="PRO_0000057575"
FT   DOMAIN          1..39
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          40..82
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..169
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          83..87
FT                   /note="Connecting peptide"
SQ   SEQUENCE   173 AA;  21367 MW;  7931BAF4144F5323 CRC64;
     MKVTFYEDRN FQGRSYDCMS DCADFSSYMS RCHSCRVHSG CWMMYDQPNY MGNQYFFRRG
     EYADYMSMFG MSNCIRSCRM IPMHRGSYRM RIYERENFMG QMYEMADDCD SIMDRYRMPH
     CQSCHVMDGH WLMYEQPHYR GRMWYFRPGE YRSFSNMGGM RFMSMRRIMD SWY