ID   CRGM3_CYPCA             Reviewed;         174 AA.
AC   P28022;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Gamma-crystallin M3;
DE            Short=Gamma-M3;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1840497; DOI=10.1016/0167-4781(91)90114-2;
RA   Chang T., Lin C.L., Chang W.C., Chen P.H.;
RT   "Gamma-crystallin genes in carp: cloning and characterization.";
RL   Biochim. Biophys. Acta 1090:261-264(1991).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; X55946; CAA39414.1; -; Genomic_DNA.
DR   PIR; S18460; S18460.
DR   AlphaFoldDB; P28022; -.
DR   SMR; P28022; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   3: Inferred from homology;
KW   Eye lens protein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..174
FT                   /note="Gamma-crystallin M3"
FT                   /id="PRO_0000057576"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..82
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          88..128
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          129..171
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          83..87
FT                   /note="Connecting peptide"
SQ   SEQUENCE   174 AA;  20950 MW;  47281946FBD31B0A CRC64;
     MGKIIFYEDR NFQGRSYECS SDCSDMSTYL SRCHSCRVES GCFVVYDVPN YMGNQFFMRR
     GEYADYMRMG MSDGIRSCRM VPQYRGPYRM RIYERENFGG QMYDLTDDCD SFVDRYRMSD
     CQSCHVMDGH WLMYEQPHYR GRIVYFRPGE YRSFRDMGYS NVKFSSVRRI MDLC