ID   CRGNA_DANRE             Reviewed;         183 AA.
AC   Q5XTN8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Gamma-crystallin N-A;
DE   AltName: Full=Gamma-N-crystallin-A;
DE   AltName: Full=GammaN1-crystallin;
GN   Name=crygna; Synonyms=crygn1; ORFNames=zgc:114194;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15853812; DOI=10.1111/j.1742-4658.2005.04655.x;
RA   Wistow G., Wyatt K., David L., Gao C., Bateman O., Bernstein S.,
RA   Tomarev S., Segovia L., Slingsby C., Vihtelic T.;
RT   "Gamma-N-crystallin and the evolution of the betagamma-crystallin
RT   superfamily in vertebrates.";
RL   FEBS J. 272:2276-2291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; AY738747; AAU85779.1; -; mRNA.
DR   EMBL; BC121745; AAI21746.1; -; mRNA.
DR   RefSeq; NP_001007785.1; NM_001007784.1.
DR   AlphaFoldDB; Q5XTN8; -.
DR   SMR; Q5XTN8; -.
DR   STRING; 7955.ENSDARP00000105491; -.
DR   PaxDb; Q5XTN8; -.
DR   Ensembl; ENSDART00000165151; ENSDARP00000134128; ENSDARG00000102129.
DR   GeneID; 493629; -.
DR   KEGG; dre:493629; -.
DR   CTD; 493629; -.
DR   ZFIN; ZDB-GENE-050225-1; crygn1.
DR   eggNOG; ENOG502QV8X; Eukaryota.
DR   GeneTree; ENSGT00940000159301; -.
DR   HOGENOM; CLU_081883_1_0_1; -.
DR   InParanoid; Q5XTN8; -.
DR   OMA; CVEVCED; -.
DR   OrthoDB; 1445128at2759; -.
DR   PhylomeDB; Q5XTN8; -.
DR   PRO; PR:Q5XTN8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000102129; Expressed in mature ovarian follicle and 15 other tissues.
DR   ExpressionAtlas; Q5XTN8; baseline.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..183
FT                   /note="Gamma-crystallin N-A"
FT                   /id="PRO_0000311283"
FT   DOMAIN          6..46
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          47..89
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          95..136
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          138..180
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
SQ   SEQUENCE   183 AA;  21511 MW;  A5C5542D49CF4D84 CRC64;
     MSQYSGKIVF FEGKCFTGRR LEVFGDCDNF QDRGFMNRVN SIRVESGAWV CFDHPDFKGQ
     QYMLEKGEYP DFQRWNGHND HMGSCKPIKM HGEQYRMELF EGQNFTGQCV ELCDDCPFLQ
     STGFSKNCLN SIKVYGDGAW AMYEEPNYRG RMYIVERGNY CAFTEWQSEN PNIQSIRRVV
     NYF