CRGNB_DANRE
ID CRGNB_DANRE Reviewed; 183 AA.
AC Q6DGY7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Gamma-crystallin N-B;
DE AltName: Full=Gamma-N-crystallin-B;
DE AltName: Full=Gamma-N2-crystallin;
GN Name=crygnb; Synonyms=crygn2; ORFNames=zgc:92717;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15853812; DOI=10.1111/j.1742-4658.2005.04655.x;
RA Wistow G., Wyatt K., David L., Gao C., Bateman O., Bernstein S.,
RA Tomarev S., Segovia L., Slingsby C., Vihtelic T.;
RT "Gamma-N-crystallin and the evolution of the betagamma-crystallin
RT superfamily in vertebrates.";
RL FEBS J. 272:2276-2291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; AY738746; AAU85778.1; -; mRNA.
DR EMBL; BC076197; AAH76197.1; -; mRNA.
DR RefSeq; NP_001003428.1; NM_001003428.3.
DR AlphaFoldDB; Q6DGY7; -.
DR SMR; Q6DGY7; -.
DR STRING; 7955.ENSDARP00000041348; -.
DR PaxDb; Q6DGY7; -.
DR PRIDE; Q6DGY7; -.
DR GeneID; 445034; -.
DR KEGG; dre:445034; -.
DR CTD; 445034; -.
DR ZFIN; ZDB-GENE-040801-16; crygn2.
DR eggNOG; ENOG502QV8X; Eukaryota.
DR InParanoid; Q6DGY7; -.
DR OrthoDB; 1445128at2759; -.
DR PhylomeDB; Q6DGY7; -.
DR TreeFam; TF331401; -.
DR PRO; PR:Q6DGY7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 2: Evidence at transcript level;
KW Eye lens protein; Reference proteome; Repeat.
FT CHAIN 1..183
FT /note="Gamma-crystallin N-B"
FT /id="PRO_0000311284"
FT DOMAIN 6..46
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 47..89
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 95..136
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 138..180
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
SQ SEQUENCE 183 AA; 21745 MW; 858CECE167F8F18E CRC64;
MSQYSGKICF YEGRCFTGRC LEVYGDCDNF QDRGFMNRVN SIRVESGAWI CYDHPDFKGQ
QYILERGEYP EFQRWNSHND HMGSCRPIRM HGEQYRMELF EGCNYTGQCM ELCDDCPFLQ
SRGFNTNCVN SVRVFGDGAW VMYEEPNFRG RMYIVERGNY CGHNEWQAQN PHIQSIRRIV
NYF
