CRGN_HUMAN
ID CRGN_HUMAN Reviewed; 182 AA.
AC Q8WXF5; Q496G6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Gamma-crystallin N {ECO:0000305};
DE AltName: Full=Gamma-N-crystallin {ECO:0000305};
GN Name=CRYGN {ECO:0000312|HGNC:HGNC:20458};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15853812; DOI=10.1111/j.1742-4658.2005.04655.x;
RA Wistow G., Wyatt K., David L., Gao C., Bateman O., Bernstein S.,
RA Tomarev S., Segovia L., Slingsby C., Vihtelic T.;
RT "Gamma-N-crystallin and the evolution of the betagamma-crystallin
RT superfamily in vertebrates.";
RL FEBS J. 272:2276-2291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WXF5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WXF5-2; Sequence=VSP_029507, VSP_029508;
CC -!- TISSUE SPECIFICITY: Not specifically expressed in eye.
CC {ECO:0000269|PubMed:15853812}.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC -!- CAUTION: In contrast to the orthologous protein found in other species,
CC the C-terminal part differs and lacks the fourth beta/gamma crystallin
CC 'Greek key' domain. Moreover, its non-specific tissue specificity
CC suggests that it may have lost its function (PubMed:15853812).
CC {ECO:0000305|PubMed:15853812}.
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DR EMBL; AF445455; AAL40968.1; -; mRNA.
DR EMBL; CH471173; EAW53992.1; -; Genomic_DNA.
DR EMBL; BC100878; AAI00879.1; -; mRNA.
DR EMBL; BC100879; AAI00880.1; -; mRNA.
DR EMBL; BC100880; AAI00881.1; -; mRNA.
DR EMBL; BC100881; AAI00882.1; -; mRNA.
DR CCDS; CCDS5926.1; -. [Q8WXF5-1]
DR CCDS; CCDS78289.1; -. [Q8WXF5-2]
DR RefSeq; NP_001295221.1; NM_001308292.1. [Q8WXF5-2]
DR RefSeq; NP_653328.1; NM_144727.2. [Q8WXF5-1]
DR RefSeq; XP_016867262.1; XM_017011773.1. [Q8WXF5-2]
DR AlphaFoldDB; Q8WXF5; -.
DR SMR; Q8WXF5; -.
DR BioGRID; 127571; 12.
DR STRING; 9606.ENSP00000338613; -.
DR iPTMnet; Q8WXF5; -.
DR PhosphoSitePlus; Q8WXF5; -.
DR BioMuta; CRYGN; -.
DR DMDM; 74727349; -.
DR PaxDb; Q8WXF5; -.
DR PRIDE; Q8WXF5; -.
DR TopDownProteomics; Q8WXF5-1; -. [Q8WXF5-1]
DR Antibodypedia; 64394; 53 antibodies from 16 providers.
DR DNASU; 155051; -.
DR Ensembl; ENST00000337323.3; ENSP00000338613.3; ENSG00000127377.10. [Q8WXF5-1]
DR Ensembl; ENST00000491928.1; ENSP00000420157.1; ENSG00000127377.10. [Q8WXF5-2]
DR GeneID; 155051; -.
DR KEGG; hsa:155051; -.
DR MANE-Select; ENST00000337323.3; ENSP00000338613.3; NM_144727.3; NP_653328.1.
DR UCSC; uc003wke.4; human. [Q8WXF5-1]
DR CTD; 155051; -.
DR GeneCards; CRYGN; -.
DR HGNC; HGNC:20458; CRYGN.
DR HPA; ENSG00000127377; Tissue enriched (thyroid).
DR MIM; 609603; gene.
DR neXtProt; NX_Q8WXF5; -.
DR PharmGKB; PA134870586; -.
DR VEuPathDB; HostDB:ENSG00000127377; -.
DR eggNOG; ENOG502QV8X; Eukaryota.
DR GeneTree; ENSGT00940000159301; -.
DR HOGENOM; CLU_081883_1_0_1; -.
DR InParanoid; Q8WXF5; -.
DR OrthoDB; 1445128at2759; -.
DR PhylomeDB; Q8WXF5; -.
DR PathwayCommons; Q8WXF5; -.
DR BioGRID-ORCS; 155051; 10 hits in 1063 CRISPR screens.
DR GenomeRNAi; 155051; -.
DR Pharos; Q8WXF5; Tdark.
DR PRO; PR:Q8WXF5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8WXF5; protein.
DR Bgee; ENSG00000127377; Expressed in right lobe of thyroid gland and 91 other tissues.
DR ExpressionAtlas; Q8WXF5; baseline and differential.
DR Genevisible; Q8WXF5; HS.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 1.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..182
FT /note="Gamma-crystallin N"
FT /id="PRO_0000311281"
FT DOMAIN 6..46
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 47..89
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 95..136
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 153..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 91..125
FT /note="HGEHFRLEIFEGCNFTGQCLEFLEDSPFLQSRGWV -> VSGPVHRRLSLPA
FT GGTEGQPWQTVARNRGAWSSRL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029507"
FT VAR_SEQ 126..182
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029508"
SQ SEQUENCE 182 AA; 20624 MW; 761F381A8BDFDDF1 CRC64;
MAQRSGKITL YEGKHFTGQK LEVFGDCDNF QDRGFMNRVN SIHVESGAWV CFNHPDFRGQ
QFILEHGDYP DFFRWNSHSD HMGSCRPVGM HGEHFRLEIF EGCNFTGQCL EFLEDSPFLQ
SRGWVKNCVN TIKVYGDGAA WSPRSFGAED FQLSSSLQSD QGPEEATTKP ATTQPPFLTA
NL
