ID   CRGN_RAT                Reviewed;         183 AA.
AC   D3ZEG1;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 3.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Gamma-crystallin N {ECO:0000305};
DE   AltName: Full=Gamma-N-crystallin {ECO:0000305};
GN   Name=Crygn {ECO:0000312|RGD:1308547};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 8-183.
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=27517863; DOI=10.1371/journal.pone.0161140;
RA   Hartwich H., Rosengauer E., Ruettiger L., Wilms V., Waterholter S.K.,
RA   Nothwang H.G.;
RT   "Functional Role of gamma-Crystallin N in the Auditory Hindbrain.";
RL   PLoS ONE 11:E0161140-E0161140(2016).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. Also plays an important role for integrity and
CC       function of auditory nuclei. {ECO:0000250|UniProtKB:Q8VHL5}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q8VHL5}.
CC   -!- TISSUE SPECIFICITY: Detected in the auditory hindbrain where it is
CC       highly expressed in the medial nucleus of the trapezoid body, but also
CC       present in other nuclei of the superior olivary complex.
CC       {ECO:0000269|PubMed:27517863}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDL99333.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AABR07059182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474020; EDL99333.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_001100043.1; NM_001106573.1.
DR   RefSeq; XP_006235944.1; XM_006235882.3.
DR   AlphaFoldDB; D3ZEG1; -.
DR   SMR; D3ZEG1; -.
DR   STRING; 10116.ENSRNOP00000012285; -.
DR   PaxDb; D3ZEG1; -.
DR   Ensembl; ENSRNOT00000109858; ENSRNOP00000093305; ENSRNOG00000009226.
DR   GeneID; 296730; -.
DR   KEGG; rno:296730; -.
DR   CTD; 155051; -.
DR   RGD; 1308547; Crygn.
DR   eggNOG; ENOG502QV8X; Eukaryota.
DR   GeneTree; ENSGT00940000159301; -.
DR   HOGENOM; CLU_081883_2_1_1; -.
DR   InParanoid; D3ZEG1; -.
DR   OrthoDB; 1445128at2759; -.
DR   PRO; PR:D3ZEG1; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Proteomes; UP000234681; Chromosome 4.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..183
FT                   /note="Gamma-crystallin N"
FT                   /id="PRO_0000444949"
FT   DOMAIN          6..46
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          47..89
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          95..136
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          138..180
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
SQ   SEQUENCE   183 AA;  21446 MW;  B20633781417CA4A CRC64;
     MAQRSGKITL YEGKHFTGRK LEVFGDCDNF QDRGFMNRVN SIRVESGAWV CFDHPDFRGQ
     QFILEHGDYP EFFRWNGHND HMGSCRPVGM HGEHFRIDIF EGCNFTGQCL EFVEDCPFLQ
     SRGWAKSCVN AIKVYGDGAW VLYEEPNYRG RMYVVERGDF RSFSDWEAHS ARVQSLRRVL
     NFF