ID   CRGN_XENTR              Reviewed;         183 AA.
AC   A4QNB6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Gamma-crystallin N;
DE   AltName: Full=Gamma-N-crystallin;
GN   Name=crygn;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI35331.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC135330; AAI35331.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001116274.1; NM_001122802.1.
DR   AlphaFoldDB; A4QNB6; -.
DR   SMR; A4QNB6; -.
DR   STRING; 8364.ENSXETP00000021426; -.
DR   PaxDb; A4QNB6; -.
DR   Ensembl; ENSXETT00000021426; ENSXETP00000021426; ENSXETG00000009726.
DR   GeneID; 100125131; -.
DR   KEGG; xtr:100125131; -.
DR   CTD; 155051; -.
DR   Xenbase; XB-GENE-949640; crygn.
DR   eggNOG; ENOG502QV8X; Eukaryota.
DR   HOGENOM; CLU_081883_1_0_1; -.
DR   InParanoid; A4QNB6; -.
DR   OrthoDB; 1445128at2759; -.
DR   PhylomeDB; A4QNB6; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009726; Expressed in embryo and 1 other tissue.
DR   GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; SSF49695; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..183
FT                   /note="Gamma-crystallin N"
FT                   /id="PRO_0000311285"
FT   DOMAIN          6..46
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          47..89
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          95..136
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          138..180
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   CONFLICT        1
FT                   /note="M -> I (in Ref. 1; AAI35331)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   183 AA;  21689 MW;  76BDD624638D0E06 CRC64;
     MSQYSGKIIF YEGKCFTGRK LEVFGDCDNF QDKGFMNRVN SIRVETGAWI CYDHPDFKGQ
     QYILERGEYP DFHRWNGHND HMGSCKPVRM HGERYRLELF EGCNFTGQCM EFCEDCPFLQ
     GRGWNKNCVN ACKVYGDGAW VLYEEPNYRG RMYIVERGDY RSFNDWQSQS ANIQSVRRVV
     NYF