CRH2_CAEEL
ID CRH2_CAEEL Reviewed; 351 AA.
AC Q4JFH9; Q09636; Q4JFI0; Q95ZX9; S6FD32;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=CREB homolog crh-2 {ECO:0000305};
GN Name=crh-2 {ECO:0000312|WormBase:C27D6.4c};
GN ORFNames=C27D6.4 {ECO:0000312|WormBase:C27D6.4c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND INDUCTION BY PATHOGEN.
RX PubMed=32963007; DOI=10.1128/mbio.01950-20;
RA Gabaldon C., Leguee M., Palominos M.F., Verdugo L., Gutzwiller F.,
RA Calixto A.;
RT "Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is
RT Modulated by mir-243.";
RL MBio 11:0-0(2020).
CC -!- FUNCTION: Transcription factor (By similarity). Plays a role in
CC regulating the developmentally arrested larval state known as dauer,
CC when induced by long-term exposure to the Gram-negative bacterium
CC P.aeruginosa PAO1, but dispensable for dauer formation induced by
CC starvation (PubMed:32963007). Involved in regulating expression of
CC microRNA mir-243, during long-term exposure to P.aeruginosa PAO1
CC (PubMed:32963007). {ECO:0000250|UniProtKB:Q96BA8,
CC ECO:0000269|PubMed:32963007}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=c {ECO:0000312|WormBase:C27D6.4c};
CC IsoId=Q4JFH9-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:C27D6.4a};
CC IsoId=Q4JFH9-2; Sequence=VSP_061111;
CC Name=b {ECO:0000312|WormBase:C27D6.4b};
CC IsoId=Q4JFH9-3; Sequence=VSP_061113;
CC Name=d {ECO:0000312|WormBase:C27D6.4d};
CC IsoId=Q4JFH9-4; Sequence=VSP_061112;
CC -!- INDUCTION: Expression up-regulated in animals exposed to the Gram-
CC negative bacterium P.aeruginosa PAO1 for two generations.
CC {ECO:0000269|PubMed:32963007}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; BX284602; CCD65811.1; -; Genomic_DNA.
DR EMBL; BX284602; CCD65812.1; -; Genomic_DNA.
DR EMBL; BX284602; CCD65813.3; -; Genomic_DNA.
DR EMBL; BX284602; CDG24138.1; -; Genomic_DNA.
DR PIR; T15656; T15656.
DR RefSeq; NP_001293486.1; NM_001306557.1. [Q4JFH9-4]
DR RefSeq; NP_740985.2; NM_170987.5. [Q4JFH9-2]
DR RefSeq; NP_740986.2; NM_170988.4. [Q4JFH9-3]
DR RefSeq; NP_740987.4; NM_170989.9. [Q4JFH9-1]
DR AlphaFoldDB; Q4JFH9; -.
DR SMR; Q4JFH9; -.
DR IntAct; Q4JFH9; 1.
DR STRING; 6239.C27D6.4c; -.
DR EPD; Q4JFH9; -.
DR EnsemblMetazoa; C27D6.4a.1; C27D6.4a.1; WBGene00016162. [Q4JFH9-2]
DR EnsemblMetazoa; C27D6.4b.1; C27D6.4b.1; WBGene00016162. [Q4JFH9-3]
DR EnsemblMetazoa; C27D6.4c.1; C27D6.4c.1; WBGene00016162. [Q4JFH9-1]
DR EnsemblMetazoa; C27D6.4d.1; C27D6.4d.1; WBGene00016162. [Q4JFH9-4]
DR GeneID; 259434; -.
DR KEGG; cel:CELE_C27D6.4; -.
DR UCSC; C27D6.4c; c. elegans.
DR CTD; 259434; -.
DR WormBase; C27D6.4a; CE32146; WBGene00016162; crh-2.
DR WormBase; C27D6.4b; CE32147; WBGene00016162; crh-2.
DR WormBase; C27D6.4c; CE48424; WBGene00016162; crh-2.
DR WormBase; C27D6.4d; CE48416; WBGene00016162; crh-2.
DR eggNOG; KOG0709; Eukaryota.
DR GeneTree; ENSGT00940000168374; -.
DR HOGENOM; CLU_076181_0_0_1; -.
DR OMA; HNFLFKD; -.
DR OrthoDB; 1598986at2759; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00016162; Expressed in larva and 4 other tissues.
DR ExpressionAtlas; Q4JFH9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035497; F:cAMP response element binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR GO; GO:1905911; P:positive regulation of dauer entry; IMP:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..351
FT /note="CREB homolog crh-2"
FT /id="PRO_0000453179"
FT DOMAIN 282..345
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 46..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..304
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 307..314
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 64..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..214
FT /note="MNSSSSRSSMSMPMPMDMPQMHMGMNNNCEMNQMMHPIPNFPMKWEPCTPPD
FT EKPHPSMLFPPLSGIFNQSRHSSTGEDYHGSSSGSPSSSLSSPNEFKDEPLGLDVHFGN
FT SLFNAPFSPSATSSHSPSSYGMMHGSHSMASHQLHQQQLSPLPSVAHFSHSHHLQHHVV
FT QHPSQASLQMNMNQIFSGPSHQYASSSVPHTFLFKDSTIYEGMG -> MATRCTANVFI
FT KDEIKEEQLEDHGIEMDLSALLNSRAGTNSHDSSPDEEEHDMTIHSEMFLAAASADGLD
FT GSEGSQEVMDVDDLLLR (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_061111"
FT VAR_SEQ 1..132
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_061112"
FT VAR_SEQ 1..78
FT /note="MNSSSSRSSMSMPMPMDMPQMHMGMNNNCEMNQMMHPIPNFPMKWEPCTPPD
FT EKPHPSMLFPPLSGIFNQSRHSSTGE -> MDDDWATSGVLEKDVFISSVHDEKDTLDI
FT LKLFDNDIDGFSDDNFRIKMEPNDETS (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061113"
SQ SEQUENCE 351 AA; 39570 MW; 1307E916ECFB95E5 CRC64;
MNSSSSRSSM SMPMPMDMPQ MHMGMNNNCE MNQMMHPIPN FPMKWEPCTP PDEKPHPSML
FPPLSGIFNQ SRHSSTGEDY HGSSSGSPSS SLSSPNEFKD EPLGLDVHFG NSLFNAPFSP
SATSSHSPSS YGMMHGSHSM ASHQLHQQQL SPLPSVAHFS HSHHLQHHVV QHPSQASLQM
NMNQIFSGPS HQYASSSVPH TFLFKDSTIY EGMGGMGLAA AQQQLKARNK MHEMAIRQHL
ITDQNITANG DLVLSAEERR TLVQEGYSIP QKYPLTKSEE ESLKIVRRKI KNKLSAQESR
RKRKEYIDAL EGRLHCFSEE NKSLKKQVHQ LEASNRDLQQ KLHQYESKEK M
