CRHBP_HUMAN
ID CRHBP_HUMAN Reviewed; 322 AA.
AC P24387; Q53F32; Q6FHT5;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Corticotropin-releasing factor-binding protein;
DE Short=CRF-BP;
DE Short=CRF-binding protein;
DE AltName: Full=Corticotropin-releasing hormone-binding protein;
DE Short=CRH-BP;
DE Flags: Precursor;
GN Name=CRHBP; Synonyms=CRFBP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Liver;
RX PubMed=1846945; DOI=10.1038/349423a0;
RA Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W.;
RT "Cloning and characterization of the cDNAs for human and rat corticotropin
RT releasing factor-binding proteins.";
RL Nature 349:423-426(1991).
RN [2]
RP SEQUENCE REVISION TO 47-48 AND 248, AND DISULFIDE BONDS.
RX PubMed=8307998; DOI=10.1016/s0021-9258(17)41780-7;
RA Fischer W.H., Behan D.P., Park M., Potter E., Lowry P.J., Vale W.W.;
RT "Assignment of disulfide bonds in corticotropin-releasing factor-binding
RT protein.";
RL J. Biol. Chem. 269:4313-4316(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
RX PubMed=8198617; DOI=10.1006/geno.1993.1141;
RA Behan D.P., Potter E., Lewis K.A., Jenkins N.A., Copeland N.G., Lowry P.J.,
RA Vale W.W.;
RT "Cloning and structure of the human corticotrophin releasing factor-binding
RT protein gene (CRHBP).";
RL Genomics 16:63-68(1993).
CC -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate
CC pituitary-adrenal stimulation in pregnancy.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the CRF-binding protein family. {ECO:0000305}.
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DR EMBL; X58022; CAA41086.1; ALT_SEQ; mRNA.
DR EMBL; S60697; AAD13916.1; -; Genomic_DNA.
DR EMBL; CR541666; CAG46467.1; -; mRNA.
DR EMBL; AK223457; BAD97177.1; -; mRNA.
DR EMBL; CH471084; EAW95786.1; -; Genomic_DNA.
DR EMBL; BC018038; AAH18038.1; -; mRNA.
DR CCDS; CCDS4034.1; -.
DR PIR; S13640; S13640.
DR RefSeq; NP_001873.2; NM_001882.3.
DR AlphaFoldDB; P24387; -.
DR BioGRID; 107783; 15.
DR IntAct; P24387; 11.
DR STRING; 9606.ENSP00000274368; -.
DR BindingDB; P24387; -.
DR ChEMBL; CHEMBL5930; -.
DR GlyConnect; 1932; 6 N-Linked glycans (1 site).
DR GlyGen; P24387; 1 site, 6 N-linked glycans (1 site).
DR iPTMnet; P24387; -.
DR PhosphoSitePlus; P24387; -.
DR BioMuta; CRHBP; -.
DR DMDM; 544099; -.
DR MassIVE; P24387; -.
DR PaxDb; P24387; -.
DR PeptideAtlas; P24387; -.
DR PRIDE; P24387; -.
DR ProteomicsDB; 54201; -.
DR Antibodypedia; 24474; 203 antibodies from 26 providers.
DR DNASU; 1393; -.
DR Ensembl; ENST00000274368.9; ENSP00000274368.4; ENSG00000145708.11.
DR GeneID; 1393; -.
DR KEGG; hsa:1393; -.
DR MANE-Select; ENST00000274368.9; ENSP00000274368.4; NM_001882.4; NP_001873.2.
DR UCSC; uc003ker.4; human.
DR CTD; 1393; -.
DR DisGeNET; 1393; -.
DR GeneCards; CRHBP; -.
DR HGNC; HGNC:2356; CRHBP.
DR HPA; ENSG00000145708; Tissue enriched (liver).
DR MIM; 122559; gene.
DR neXtProt; NX_P24387; -.
DR OpenTargets; ENSG00000145708; -.
DR PharmGKB; PA26873; -.
DR VEuPathDB; HostDB:ENSG00000145708; -.
DR eggNOG; ENOG502QRNI; Eukaryota.
DR GeneTree; ENSGT00390000001362; -.
DR HOGENOM; CLU_056739_0_0_1; -.
DR InParanoid; P24387; -.
DR OMA; IEEFCFP; -.
DR OrthoDB; 1361570at2759; -.
DR PhylomeDB; P24387; -.
DR TreeFam; TF105383; -.
DR PathwayCommons; P24387; -.
DR Reactome; R-HSA-373080; Class B/2 (Secretin family receptors).
DR SignaLink; P24387; -.
DR BioGRID-ORCS; 1393; 8 hits in 1063 CRISPR screens.
DR ChiTaRS; CRHBP; human.
DR GeneWiki; CRHBP; -.
DR GenomeRNAi; 1393; -.
DR Pharos; P24387; Tbio.
DR PRO; PR:P24387; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P24387; protein.
DR Bgee; ENSG00000145708; Expressed in spleen and 112 other tissues.
DR ExpressionAtlas; P24387; baseline and differential.
DR Genevisible; P24387; HS.
DR GO; GO:0043679; C:axon terminus; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0031045; C:dense core granule; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR GO; GO:0005771; C:multivesicular body; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0005767; C:secondary lysosome; ISS:UniProtKB.
DR GO; GO:0030141; C:secretory granule; IDA:UniProtKB.
DR GO; GO:0043196; C:varicosity; ISS:UniProtKB.
DR GO; GO:0051424; F:corticotropin-releasing hormone binding; IDA:UniProtKB.
DR GO; GO:0042277; F:peptide binding; ISS:UniProtKB.
DR GO; GO:0048149; P:behavioral response to ethanol; IMP:UniProtKB.
DR GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR GO; GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
DR GO; GO:0071314; P:cellular response to cocaine; ISS:UniProtKB.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
DR GO; GO:0071391; P:cellular response to estrogen stimulus; IDA:UniProtKB.
DR GO; GO:0097211; P:cellular response to gonadotropin-releasing hormone; ISS:UniProtKB.
DR GO; GO:0035865; P:cellular response to potassium ion; IDA:UniProtKB.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; ISS:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; IDA:UniProtKB.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IDA:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IDA:UniProtKB.
DR GO; GO:0007611; P:learning or memory; TAS:UniProtKB.
DR GO; GO:0051460; P:negative regulation of corticotropin secretion; IDA:UniProtKB.
DR GO; GO:1900011; P:negative regulation of corticotropin-releasing hormone receptor activity; IDA:UniProtKB.
DR GO; GO:0045055; P:regulated exocytosis; IDA:UniProtKB.
DR GO; GO:0080135; P:regulation of cellular response to stress; IMP:UniProtKB.
DR GO; GO:0051459; P:regulation of corticotropin secretion; IDA:UniProtKB.
DR GO; GO:2000310; P:regulation of NMDA receptor activity; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; TAS:UniProtKB.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; ISS:UniProtKB.
DR Gene3D; 2.60.120.290; -; 1.
DR InterPro; IPR008435; CRF-bd.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR10278; PTHR10278; 1.
DR Pfam; PF05428; CRF-BP; 1.
DR PIRSF; PIRSF009279; CRF_bd; 1.
DR SUPFAM; SSF49854; SSF49854; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT CHAIN 25..322
FT /note="Corticotropin-releasing factor-binding protein"
FT /id="PRO_0000020994"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 60..81
FT /evidence="ECO:0000269|PubMed:8307998"
FT DISULFID 104..141
FT /evidence="ECO:0000269|PubMed:8307998"
FT DISULFID 183..205
FT /evidence="ECO:0000269|PubMed:8307998"
FT DISULFID 237..264
FT /evidence="ECO:0000269|PubMed:8307998"
FT DISULFID 277..318
FT /evidence="ECO:0000269|PubMed:8307998"
FT CONFLICT 279
FT /note="N -> D (in Ref. 4; BAD97177)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 322 AA; 36144 MW; 771A894BE06039BD CRC64;
MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC
LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG
EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL
FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI
GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ
LEPYELENPN GNSIGEFCLS GL
