CRHBP_MOUSE
ID CRHBP_MOUSE Reviewed; 322 AA.
AC Q60571;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Corticotropin-releasing factor-binding protein;
DE Short=CRF-BP;
DE Short=CRF-binding protein;
DE AltName: Full=Corticotropin-releasing hormone-binding protein;
DE Short=CRH-BP;
DE Flags: Precursor;
GN Name=Crhbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=7556876; DOI=10.1016/0303-7207(95)03558-o;
RA Cortright D.N., Nicoletti A., Seasholtz A.F.;
RT "Molecular and biochemical characterization of the mouse brain
RT corticotropin-releasing hormone-binding protein.";
RL Mol. Cell. Endocrinol. 111:147-157(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate
CC pituitary-adrenal stimulation in pregnancy.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRF-binding protein family. {ECO:0000305}.
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DR EMBL; U33323; AAC52253.1; -; mRNA.
DR EMBL; BC061247; AAH61247.1; -; mRNA.
DR CCDS; CCDS26698.1; -.
DR RefSeq; NP_940800.1; NM_198408.3.
DR AlphaFoldDB; Q60571; -.
DR SMR; Q60571; -.
DR STRING; 10090.ENSMUSP00000042578; -.
DR GlyConnect; 2237; 2 N-Linked glycans (1 site).
DR GlyGen; Q60571; 1 site, 2 N-linked glycans (1 site).
DR PhosphoSitePlus; Q60571; -.
DR PaxDb; Q60571; -.
DR PRIDE; Q60571; -.
DR ProteomicsDB; 283956; -.
DR Antibodypedia; 24474; 203 antibodies from 26 providers.
DR DNASU; 12919; -.
DR Ensembl; ENSMUST00000221025; ENSMUSP00000152083; ENSMUSG00000021680.
DR GeneID; 12919; -.
DR KEGG; mmu:12919; -.
DR UCSC; uc007rmk.2; mouse.
DR CTD; 1393; -.
DR MGI; MGI:88497; Crhbp.
DR VEuPathDB; HostDB:ENSMUSG00000021680; -.
DR eggNOG; ENOG502QRNI; Eukaryota.
DR GeneTree; ENSGT00390000001362; -.
DR HOGENOM; CLU_056739_0_0_1; -.
DR InParanoid; Q60571; -.
DR OMA; IEEFCFP; -.
DR OrthoDB; 1361570at2759; -.
DR PhylomeDB; Q60571; -.
DR TreeFam; TF105383; -.
DR Reactome; R-MMU-373080; Class B/2 (Secretin family receptors).
DR BioGRID-ORCS; 12919; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Crhbp; mouse.
DR PRO; PR:Q60571; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q60571; protein.
DR Bgee; ENSMUSG00000021680; Expressed in vestibular membrane of cochlear duct and 53 other tissues.
DR ExpressionAtlas; Q60571; baseline and differential.
DR Genevisible; Q60571; MM.
DR GO; GO:0043679; C:axon terminus; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0031045; C:dense core granule; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR GO; GO:0005771; C:multivesicular body; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0005767; C:secondary lysosome; ISS:UniProtKB.
DR GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
DR GO; GO:0043196; C:varicosity; ISS:UniProtKB.
DR GO; GO:0051424; F:corticotropin-releasing hormone binding; IDA:MGI.
DR GO; GO:0042277; F:peptide binding; ISS:UniProtKB.
DR GO; GO:0048149; P:behavioral response to ethanol; ISS:UniProtKB.
DR GO; GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.
DR GO; GO:0071320; P:cellular response to cAMP; IDA:UniProtKB.
DR GO; GO:0071314; P:cellular response to cocaine; ISS:UniProtKB.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
DR GO; GO:0071391; P:cellular response to estrogen stimulus; ISS:UniProtKB.
DR GO; GO:0097211; P:cellular response to gonadotropin-releasing hormone; IDA:UniProtKB.
DR GO; GO:0035903; P:cellular response to immobilization stress; ISS:UniProtKB.
DR GO; GO:0035865; P:cellular response to potassium ion; ISS:UniProtKB.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IDA:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; ISS:UniProtKB.
DR GO; GO:0042445; P:hormone metabolic process; IDA:MGI.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0002125; P:maternal aggressive behavior; IMP:UniProtKB.
DR GO; GO:0051460; P:negative regulation of corticotropin secretion; ISS:UniProtKB.
DR GO; GO:1900011; P:negative regulation of corticotropin-releasing hormone receptor activity; ISS:UniProtKB.
DR GO; GO:0045055; P:regulated exocytosis; ISS:UniProtKB.
DR GO; GO:0080135; P:regulation of cellular response to stress; ISS:UniProtKB.
DR GO; GO:0051459; P:regulation of corticotropin secretion; ISS:UniProtKB.
DR GO; GO:2000310; P:regulation of NMDA receptor activity; IDA:UniProtKB.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; IDA:UniProtKB.
DR InterPro; IPR008435; CRF-bd.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR10278; PTHR10278; 1.
DR Pfam; PF05428; CRF-BP; 1.
DR PIRSF; PIRSF009279; CRF_bd; 1.
DR SUPFAM; SSF49854; SSF49854; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..322
FT /note="Corticotropin-releasing factor-binding protein"
FT /id="PRO_0000020995"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 60..81
FT /evidence="ECO:0000250"
FT DISULFID 104..141
FT /evidence="ECO:0000250"
FT DISULFID 183..205
FT /evidence="ECO:0000250"
FT DISULFID 237..264
FT /evidence="ECO:0000250"
FT DISULFID 277..318
FT /evidence="ECO:0000250"
SQ SEQUENCE 322 AA; 36048 MW; 2F8A5D80CD54C7BC CRC64;
MSPNFKLQCH FILILLTALR GESRYLEVQE AAVYDPLLLF SANLKRDLAE EQPYRRALRC
LDMLSLPGQF TFTADRPQLH CAAFFIGEPE EFITIHYDLV SIDCQGGDFL KVFDGWILKG
EKFPSSQDHP LPTMKRYTDF CESGLTRRSI RSSQNVAMVF FRVHEPGNGF TITIKTDPNL
FPCNVISQTP SGRFTLVVPY QHQNCSFSII YPVAIKISDL TLGHLHGLQL KKPAAGCGGT
GDFVELLGGT GLDPSKMMPL ADLCYPFLGP AQMKISCDNA VVRMVSSGKH INRVTFEYRQ
LEPFELETST GNSIPEYCLS SL
