ID   CRHBP_RAT               Reviewed;         322 AA.
AC   P24388;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Corticotropin-releasing factor-binding protein;
DE            Short=CRF-BP;
DE            Short=CRF-binding protein;
DE   AltName: Full=Corticotropin-releasing hormone-binding protein;
DE            Short=CRH-BP;
DE   Flags: Precursor;
GN   Name=Crhbp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1846945; DOI=10.1038/349423a0;
RA   Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., Vale W.W.;
RT   "Cloning and characterization of the cDNAs for human and rat corticotropin
RT   releasing factor-binding proteins.";
RL   Nature 349:423-426(1991).
CC   -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate
CC       pituitary-adrenal stimulation in pregnancy.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRF-binding protein family. {ECO:0000305}.
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DR   EMBL; X58023; CAA41087.1; -; mRNA.
DR   PIR; S13955; S13955.
DR   AlphaFoldDB; P24388; -.
DR   STRING; 10116.ENSRNOP00000024191; -.
DR   GlyGen; P24388; 1 site.
DR   PaxDb; P24388; -.
DR   UCSC; RGD:2403; rat.
DR   RGD; 2403; Crhbp.
DR   eggNOG; ENOG502QRNI; Eukaryota.
DR   InParanoid; P24388; -.
DR   PhylomeDB; P24388; -.
DR   Reactome; R-RNO-373080; Class B/2 (Secretin family receptors).
DR   PRO; PR:P24388; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0043679; C:axon terminus; IDA:RGD.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0031045; C:dense core granule; IDA:RGD.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005874; C:microtubule; IDA:RGD.
DR   GO; GO:0005771; C:multivesicular body; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; IDA:RGD.
DR   GO; GO:0005767; C:secondary lysosome; IDA:RGD.
DR   GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
DR   GO; GO:0043196; C:varicosity; IDA:RGD.
DR   GO; GO:0051424; F:corticotropin-releasing hormone binding; IDA:RGD.
DR   GO; GO:0042277; F:peptide binding; IDA:RGD.
DR   GO; GO:0048149; P:behavioral response to ethanol; ISS:UniProtKB.
DR   GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR   GO; GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
DR   GO; GO:0071314; P:cellular response to cocaine; IDA:UniProtKB.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
DR   GO; GO:0071391; P:cellular response to estrogen stimulus; IDA:UniProtKB.
DR   GO; GO:0097211; P:cellular response to gonadotropin-releasing hormone; ISS:UniProtKB.
DR   GO; GO:0035903; P:cellular response to immobilization stress; IDA:UniProtKB.
DR   GO; GO:0035865; P:cellular response to potassium ion; ISS:UniProtKB.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; ISS:UniProtKB.
DR   GO; GO:0007565; P:female pregnancy; ISO:RGD.
DR   GO; GO:0042445; P:hormone metabolic process; IEP:RGD.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR   GO; GO:0002125; P:maternal aggressive behavior; ISS:UniProtKB.
DR   GO; GO:0051460; P:negative regulation of corticotropin secretion; IDA:UniProtKB.
DR   GO; GO:1900011; P:negative regulation of corticotropin-releasing hormone receptor activity; ISS:UniProtKB.
DR   GO; GO:0045055; P:regulated exocytosis; ISS:UniProtKB.
DR   GO; GO:0080135; P:regulation of cellular response to stress; ISO:RGD.
DR   GO; GO:0051459; P:regulation of corticotropin secretion; ISS:UniProtKB.
DR   GO; GO:2000310; P:regulation of NMDA receptor activity; ISS:UniProtKB.
DR   GO; GO:0001963; P:synaptic transmission, dopaminergic; IEP:UniProtKB.
DR   Gene3D; 2.60.120.290; -; 1.
DR   InterPro; IPR008435; CRF-bd.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR10278; PTHR10278; 1.
DR   Pfam; PF05428; CRF-BP; 1.
DR   PIRSF; PIRSF009279; CRF_bd; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..322
FT                   /note="Corticotropin-releasing factor-binding protein"
FT                   /id="PRO_0000020996"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        60..81
FT                   /evidence="ECO:0000250"
FT   DISULFID        104..141
FT                   /evidence="ECO:0000250"
FT   DISULFID        183..205
FT                   /evidence="ECO:0000250"
FT   DISULFID        237..264
FT                   /evidence="ECO:0000250"
FT   DISULFID        277..318
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   322 AA;  36121 MW;  59B33CC57159AC76 CRC64;
     MSPNFKLQCH FTLILLTALR GESRYLEVQE AAVYDPFLLF SANLKRNLAE EQPYRRALRC
     LDMLSLPGQF TFTADQPQLH CAAFFIGEPE EFITIHFDLV SIDCQGGDFL KVFDGWILKG
     EKFPSSQDHP LPTRERYTDF CESGLTRRSV TSSQNVAMVF FRVHEPGNGF TITIKTDPNL
     FPCNIISQTP SGRFALVVPY QHQNCSFSII YPVTIKISDL ALGHLHGLQL KKPAAGCGGT
     GDFVELLGGT GLDTSKMMLL VDLCYPFHGP AQMKISCDNA VVRMVSSGKH MNRVTFEYRQ
     LEPLELETST RNSIPEYCLS SL