CRHBP_SHEEP
ID CRHBP_SHEEP Reviewed; 324 AA.
AC Q28557;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Corticotropin-releasing factor-binding protein;
DE Short=CRF-BP;
DE Short=CRF-binding protein;
DE AltName: Full=Corticotropin-releasing hormone-binding protein;
DE Short=CRH-BP;
DE Flags: Precursor;
GN Name=CRHBP;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8833763; DOI=10.1016/0006-8993(95)01317-2;
RA Behan D.P., Cepoi D., Fischer W.H., Park M., Sutton S., Lowry P.J.,
RA Vale W.;
RT "Characterization of a sheep brain corticotropin releasing factor binding
RT protein.";
RL Brain Res. 709:265-274(1996).
RN [2]
RP ERRATUM OF PUBMED:8833763.
RX PubMed=8891296; DOI=10.1016/0006-8993(96)00625-7;
RA Behan D.P., Cepoi D., Fischer W.H., Park M., Sutton S., Lowry P.J.,
RA Vale W.;
RL Brain Res. 732:267-267(1996).
CC -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate
CC pituitary-adrenal stimulation in pregnancy.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRF-binding protein family. {ECO:0000305}.
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DR EMBL; U51199; AAC48545.1; -; mRNA.
DR RefSeq; NP_001009339.1; NM_001009339.1.
DR AlphaFoldDB; Q28557; -.
DR GeneID; 443354; -.
DR KEGG; oas:443354; -.
DR CTD; 1393; -.
DR OrthoDB; 1361570at2759; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0043679; C:axon terminus; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0031045; C:dense core granule; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR GO; GO:0005771; C:multivesicular body; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; ISS:UniProtKB.
DR GO; GO:0005767; C:secondary lysosome; ISS:UniProtKB.
DR GO; GO:0030141; C:secretory granule; ISS:UniProtKB.
DR GO; GO:0043196; C:varicosity; ISS:UniProtKB.
DR GO; GO:0051424; F:corticotropin-releasing hormone binding; ISS:UniProtKB.
DR GO; GO:0042277; F:peptide binding; ISS:UniProtKB.
DR GO; GO:0048149; P:behavioral response to ethanol; ISS:UniProtKB.
DR GO; GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
DR GO; GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
DR GO; GO:0071314; P:cellular response to cocaine; ISS:UniProtKB.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0071391; P:cellular response to estrogen stimulus; ISS:UniProtKB.
DR GO; GO:0097211; P:cellular response to gonadotropin-releasing hormone; ISS:UniProtKB.
DR GO; GO:0035903; P:cellular response to immobilization stress; ISS:UniProtKB.
DR GO; GO:0035865; P:cellular response to potassium ion; ISS:UniProtKB.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; ISS:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; ISS:UniProtKB.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0002125; P:maternal aggressive behavior; ISS:UniProtKB.
DR GO; GO:0051460; P:negative regulation of corticotropin secretion; ISS:UniProtKB.
DR GO; GO:1900011; P:negative regulation of corticotropin-releasing hormone receptor activity; ISS:UniProtKB.
DR GO; GO:0045055; P:regulated exocytosis; ISS:UniProtKB.
DR GO; GO:0080135; P:regulation of cellular response to stress; ISS:UniProtKB.
DR GO; GO:0051459; P:regulation of corticotropin secretion; ISS:UniProtKB.
DR GO; GO:2000310; P:regulation of NMDA receptor activity; ISS:UniProtKB.
DR GO; GO:0001963; P:synaptic transmission, dopaminergic; ISS:UniProtKB.
DR InterPro; IPR008435; CRF-bd.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR10278; PTHR10278; 1.
DR Pfam; PF05428; CRF-BP; 1.
DR PIRSF; PIRSF009279; CRF_bd; 1.
DR SUPFAM; SSF49854; SSF49854; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..324
FT /note="Corticotropin-releasing factor-binding protein"
FT /id="PRO_0000020997"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 62..83
FT /evidence="ECO:0000250"
FT DISULFID 106..143
FT /evidence="ECO:0000250"
FT DISULFID 185..207
FT /evidence="ECO:0000250"
FT DISULFID 239..266
FT /evidence="ECO:0000250"
FT DISULFID 279..320
FT /evidence="ECO:0000250"
SQ SEQUENCE 324 AA; 36387 MW; ED927A9E131CE6B2 CRC64;
MAPTLKLQCH FILVCLLALR GESRYLELRE AVDHDPFPHL AGGASPKREL EGEPLYRRAL
RCVDMLSLQG QFTFTADRRQ LHCATFFIAE PEEFITIHYD LVSIDCLRGD ILQVFDGWIL
KGEKFPSSQD HPLPTTERYV DFCDSGLSRR SIRSSQNVAM IFFRVHEPGN GFTITVKTEP
NLFPCNIISQ TPNGRFTLVM PHQHRNCSFS IIYPVAIKIS DLTLGHLNGL QLKKSSAGCG
GIGDFVELLG GTGLDPSKML LLADLCYPLR GPAQMKVGCD HTVLRMVSSG KHINRVTFEY
RQLEPYELEN PNGNSIQEFC LSTL
