ID   CRHBP_XENLA             Reviewed;         321 AA.
AC   Q91653; A1L2Q7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Corticotropin-releasing factor-binding protein;
DE            Short=CRF-BP;
DE            Short=CRF-binding protein;
DE   AltName: Full=Corticotropin-releasing hormone-binding protein;
DE            Short=CRH-BP;
DE   Flags: Precursor;
GN   Name=crhbp; Synonyms=e;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8700860; DOI=10.1073/pnas.93.5.1924;
RA   Brown D.D., Wang Z., Furlow J.D., Kanamori A., Schwartzman R.A., Remo B.F.,
RA   Pinder A.;
RT   "The thyroid hormone-induced tail resorption program during Xenopus laevis
RT   metamorphosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:1924-1929(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory bulb;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds CRF and inactivates it. May prevent inappropriate
CC       pituitary-adrenal stimulation in pregnancy (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRF-binding protein family. {ECO:0000305}.
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DR   EMBL; U41858; AAC59874.1; -; mRNA.
DR   EMBL; BC129661; AAI29662.1; -; mRNA.
DR   RefSeq; NP_001079273.1; NM_001085804.1.
DR   AlphaFoldDB; Q91653; -.
DR   PRIDE; Q91653; -.
DR   GeneID; 378555; -.
DR   KEGG; xla:378555; -.
DR   CTD; 378555; -.
DR   Xenbase; XB-GENE-865598; crhbp.S.
DR   OMA; AEPNQVI; -.
DR   OrthoDB; 1361570at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 378555; Expressed in internal ear and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0051424; F:corticotropin-releasing hormone binding; IEA:InterPro.
DR   InterPro; IPR008435; CRF-bd.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR10278; PTHR10278; 1.
DR   Pfam; PF05428; CRF-BP; 1.
DR   PIRSF; PIRSF009279; CRF_bd; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..321
FT                   /note="Corticotropin-releasing factor-binding protein"
FT                   /id="PRO_0000020998"
FT   CARBOHYD        203
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        59..80
FT                   /evidence="ECO:0000250"
FT   DISULFID        103..140
FT                   /evidence="ECO:0000250"
FT   DISULFID        182..204
FT                   /evidence="ECO:0000250"
FT   DISULFID        237..264
FT                   /evidence="ECO:0000250"
FT   DISULFID        277..317
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   321 AA;  36295 MW;  7657861F32FDDE3E CRC64;
     MTPASRPDWC LILLFLAVLR GESRYIQMRE AAEDALFLLN SDFKRELSEG QIYRRSLRCI
     DMLSIEGQFT FQADRPQLHC ALFLIGEPEE FIIIEYNFVN IDCIGGDILK VFDGWIIKGE
     KFPSSLDHPL STMERYTDIC EDGDVGSITR SSQNVAMIFF RVQQPGHGFT LTIRKIPNLF
     PCNVISQSMN GRFTMITPHQ HRNCSFSIIY PVVIKIFDLT LGHFNELQLK KPPPKGCGDA
     GDFVELLGGA GLDPSKMFPL ADLCHSFHGS AQMKIGCDNT VVRMVSSGNF INRVTFEYNQ
     LDRQLEKKQG NSVEEACFPS D