ID   CRI3_CAEEL              Reviewed;         236 AA.
AC   Q21018;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Conserved regulator of innate immunity protein 3;
DE   Flags: Precursor;
GN   Name=cri-3; ORFNames=F59A2.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- INTERACTION:
CC       Q21018; O45799: scrm-1; NbExp=3; IntAct=EBI-323476, EBI-312683;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MAM33 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z34801; CAA84328.1; -; Genomic_DNA.
DR   PIR; T22972; T22972.
DR   RefSeq; NP_497701.1; NM_065300.4.
DR   AlphaFoldDB; Q21018; -.
DR   SMR; Q21018; -.
DR   BioGRID; 40683; 22.
DR   DIP; DIP-26630N; -.
DR   IntAct; Q21018; 5.
DR   MINT; Q21018; -.
DR   STRING; 6239.F59A2.3; -.
DR   EPD; Q21018; -.
DR   PaxDb; Q21018; -.
DR   PeptideAtlas; Q21018; -.
DR   EnsemblMetazoa; F59A2.3.1; F59A2.3.1; WBGene00010303.
DR   EnsemblMetazoa; F59A2.3.2; F59A2.3.2; WBGene00010303.
DR   GeneID; 175441; -.
DR   UCSC; F59A2.3.1; c. elegans.
DR   CTD; 175441; -.
DR   WormBase; F59A2.3; CE17940; WBGene00010303; cri-3.
DR   eggNOG; KOG4024; Eukaryota.
DR   GeneTree; ENSGT00390000018406; -.
DR   HOGENOM; CLU_1176395_0_0_1; -.
DR   InParanoid; Q21018; -.
DR   OMA; FRVEEFY; -.
DR   OrthoDB; 888304at2759; -.
DR   PhylomeDB; Q21018; -.
DR   Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR   Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR   PRO; PR:Q21018; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00010303; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0042256; P:mature ribosome assembly; IBA:GO_Central.
DR   Gene3D; 3.10.280.10; -; 1.
DR   InterPro; IPR003428; MAM33.
DR   InterPro; IPR036561; MAM33_sf.
DR   PANTHER; PTHR10826; PTHR10826; 1.
DR   Pfam; PF02330; MAM33; 1.
DR   SUPFAM; SSF54529; SSF54529; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..36
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..236
FT                   /note="Conserved regulator of innate immunity protein 3"
FT                   /id="PRO_0000018593"
SQ   SEQUENCE   236 AA;  26411 MW;  1101E085E47D37C3 CRC64;
     MNTASLVRSL SRVALRSSQV VRMAAPRHFS QSAKVLSVTP ELQQALNREI EAEQQLSSDN
     LQGAVAPTFA GFQVTNKDAE VRLTKKNGSE DILVVFNVNH SVDMDEGFDD EPSQAVAPVP
     VAMPPFTVEI TKGDQRLCFH LELVPVDDQP DEYDFRVEEF YVAPSAKNGN EDVPSEVYAS
     SGKYIDPDLH DLLFVRYLEE RGLDARFCKT LVAYATHYEH SQYVGLLDKI KKFISK