CRIP3_HUMAN
ID CRIP3_HUMAN Reviewed; 217 AA.
AC Q6Q6R5; A2A436; Q5T043; Q6Q6R4; Q6Q6R6; Q6Q6R7;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Cysteine-rich protein 3;
DE Short=CRP-3;
DE AltName: Full=Chromosome 6 LIM domain only protein;
DE Short=h6LIMo;
GN Name=CRIP3; Synonyms=CRP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND TISSUE
RP SPECIFICITY.
RX PubMed=15380775; DOI=10.1016/j.micinf.2004.06.002;
RA Casrouge A., Veitia R., Kirchner J., Bevan M.J., Kanellopoulos J.;
RT "The human and mouse orthologous LIM-only proteins respectively encoded in
RT chromosome 6 and 17 show a different expression pattern.";
RL Microbes Infect. 6:1063-1072(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- INTERACTION:
CC Q6Q6R5-3; Q13643: FHL3; NbExp=3; IntAct=EBI-12925520, EBI-741101;
CC Q6Q6R5-3; O60568: PLOD3; NbExp=3; IntAct=EBI-12925520, EBI-741582;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=C;
CC IsoId=Q6Q6R5-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q6Q6R5-2; Sequence=VSP_017392;
CC Name=3; Synonyms=A;
CC IsoId=Q6Q6R5-3; Sequence=VSP_017393;
CC Name=4; Synonyms=D;
CC IsoId=Q6Q6R5-4; Sequence=VSP_017391;
CC -!- TISSUE SPECIFICITY: Expressed in most tissues, but not in skeletal
CC muscle. {ECO:0000269|PubMed:15380775}.
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DR EMBL; AY555741; AAS66887.1; -; mRNA.
DR EMBL; AY555742; AAS66888.1; -; mRNA.
DR EMBL; AY555743; AAS66889.1; -; mRNA.
DR EMBL; AY555744; AAS66890.1; -; mRNA.
DR EMBL; AL583834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS4894.2; -. [Q6Q6R5-3]
DR RefSeq; NP_996805.2; NM_206922.2. [Q6Q6R5-3]
DR RefSeq; XP_005249160.1; XM_005249103.3.
DR RefSeq; XP_011512911.1; XM_011514609.2.
DR AlphaFoldDB; Q6Q6R5; -.
DR BioGRID; 135005; 2.
DR IntAct; Q6Q6R5; 2.
DR STRING; 9606.ENSP00000361650; -.
DR iPTMnet; Q6Q6R5; -.
DR PhosphoSitePlus; Q6Q6R5; -.
DR SwissPalm; Q6Q6R5; -.
DR BioMuta; CRIP3; -.
DR DMDM; 92087061; -.
DR EPD; Q6Q6R5; -.
DR MassIVE; Q6Q6R5; -.
DR PaxDb; Q6Q6R5; -.
DR PeptideAtlas; Q6Q6R5; -.
DR PRIDE; Q6Q6R5; -.
DR ProteomicsDB; 67271; -. [Q6Q6R5-1]
DR ProteomicsDB; 67272; -. [Q6Q6R5-2]
DR ProteomicsDB; 67273; -. [Q6Q6R5-3]
DR ProteomicsDB; 67274; -. [Q6Q6R5-4]
DR Antibodypedia; 50337; 8 antibodies from 7 providers.
DR DNASU; 401262; -.
DR Ensembl; ENST00000274990.4; ENSP00000274990.4; ENSG00000146215.14. [Q6Q6R5-1]
DR Ensembl; ENST00000372569.8; ENSP00000361650.3; ENSG00000146215.14. [Q6Q6R5-3]
DR GeneID; 401262; -.
DR KEGG; hsa:401262; -.
DR MANE-Select; ENST00000372569.8; ENSP00000361650.3; NM_206922.3; NP_996805.2. [Q6Q6R5-3]
DR UCSC; uc003ouu.2; human. [Q6Q6R5-1]
DR CTD; 401262; -.
DR DisGeNET; 401262; -.
DR GeneCards; CRIP3; -.
DR HGNC; HGNC:17751; CRIP3.
DR HPA; ENSG00000146215; Tissue enhanced (heart muscle, testis).
DR neXtProt; NX_Q6Q6R5; -.
DR OpenTargets; ENSG00000146215; -.
DR PharmGKB; PA134929489; -.
DR VEuPathDB; HostDB:ENSG00000146215; -.
DR eggNOG; KOG1700; Eukaryota.
DR GeneTree; ENSGT00940000161321; -.
DR HOGENOM; CLU_054591_2_0_1; -.
DR InParanoid; Q6Q6R5; -.
DR OMA; RCEKPVF; -.
DR OrthoDB; 1214165at2759; -.
DR PhylomeDB; Q6Q6R5; -.
DR TreeFam; TF313758; -.
DR PathwayCommons; Q6Q6R5; -.
DR SignaLink; Q6Q6R5; -.
DR BioGRID-ORCS; 401262; 17 hits in 1069 CRISPR screens.
DR ChiTaRS; CRIP3; human.
DR GenomeRNAi; 401262; -.
DR Pharos; Q6Q6R5; Tdark.
DR PRO; PR:Q6Q6R5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6Q6R5; protein.
DR Bgee; ENSG00000146215; Expressed in apex of heart and 109 other tissues.
DR ExpressionAtlas; Q6Q6R5; baseline and differential.
DR Genevisible; Q6Q6R5; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; LIM domain; Metal-binding;
KW Reference proteome; Repeat; Zinc.
FT CHAIN 1..217
FT /note="Cysteine-rich protein 3"
FT /id="PRO_0000225638"
FT DOMAIN 3..64
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 122..183
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 84..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 166..217
FT /note="HDGVPYCHVPCYGYLFGPKGGQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG
FT -> V (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15380775"
FT /id="VSP_017391"
FT VAR_SEQ 186..217
FT /note="GQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG -> VNIGDVGCYIYDPVKI
FT KFK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15380775"
FT /id="VSP_017393"
FT VAR_SEQ 205..217
FT /note="HGLWVCVDNFPCG -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15380775"
FT /id="VSP_017392"
FT CONFLICT 141
FT /note="G -> S (in Ref. 1; AAS66887/AAS66888/AAS66889/
FT AAS66890)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="C -> R (in Ref. 1; AAS66887/AAS66888/AAS66889/
FT AAS66890)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 24088 MW; B8FC618E29AE244F CRC64;
MSWTCPRCQQ PVFFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA
LFGPRGVNIG GVGSYLYNPP TPSPGCTTPL SPSSFSPPRP RTGLPQGKKS PPHMKTFTGE
TSLCPGCGEP VYFAEKVMSL GRNWHRPCLR CQRCHKTLTA GSHAEHDGVP YCHVPCYGYL
FGPKGGQPHP RHWDGMYMPE VWHVHGLWVC VDNFPCG
