CRIP3_MOUSE
ID CRIP3_MOUSE Reviewed; 204 AA.
AC Q6Q6R3; E9Q860; Q14B40; Q91V23; Q91V60;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Cysteine-rich protein 3;
DE Short=CRP-3;
DE AltName: Full=Thymus LIM protein;
DE Short=m17TLP;
GN Name=Crip3; Synonyms=Tlp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=11713292; DOI=10.1128/mcb.21.24.8592-8604.2001;
RA Kirchner J., Forbush K.A., Bevan M.J.;
RT "Identification and characterization of thymus LIM protein: targeted
RT disruption reduces thymus cellularity.";
RL Mol. Cell. Biol. 21:8592-8604(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=15380775; DOI=10.1016/j.micinf.2004.06.002;
RA Casrouge A., Veitia R., Kirchner J., Bevan M.J., Kanellopoulos J.;
RT "The human and mouse orthologous LIM-only proteins respectively encoded in
RT chromosome 6 and 17 show a different expression pattern.";
RL Microbes Infect. 6:1063-1072(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11713292}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=3; Synonyms=TLP-A;
CC IsoId=Q6Q6R3-3; Sequence=Displayed;
CC Name=1; Synonyms=TLP-C;
CC IsoId=Q6Q6R3-1; Sequence=VSP_061232;
CC Name=2; Synonyms=TLP-B;
CC IsoId=Q6Q6R3-2; Sequence=VSP_061233;
CC -!- TISSUE SPECIFICITY: Expressed specifically by the thymus.
CC {ECO:0000269|PubMed:11713292}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS66891.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF367970; AAK60524.1; -; mRNA.
DR EMBL; AF367971; AAK60525.1; -; mRNA.
DR EMBL; AF367972; AAK60926.1; -; Genomic_DNA.
DR EMBL; AF367972; AAK60925.1; -; Genomic_DNA.
DR EMBL; AY555745; AAS66891.1; ALT_FRAME; mRNA.
DR EMBL; AK080272; BAC37863.1; -; mRNA.
DR EMBL; GL456179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116360; AAI16361.1; -; mRNA.
DR CCDS; CCDS28828.1; -. [Q6Q6R3-3]
DR CCDS; CCDS37635.1; -. [Q6Q6R3-2]
DR RefSeq; NP_444480.1; NM_053250.2.
DR RefSeq; NP_858050.1; NM_181664.2. [Q6Q6R3-3]
DR AlphaFoldDB; Q6Q6R3; -.
DR STRING; 10090.ENSMUSP00000109092; -.
DR PhosphoSitePlus; Q6Q6R3; -.
DR PRIDE; Q6Q6R3; -.
DR ProteomicsDB; 284015; -. [Q6Q6R3-1]
DR ProteomicsDB; 284016; -. [Q6Q6R3-2]
DR ProteomicsDB; 284017; -. [Q6Q6R3-3]
DR ProteomicsDB; 367252; -.
DR Antibodypedia; 50337; 8 antibodies from 7 providers.
DR DNASU; 114570; -.
DR GeneID; 114570; -.
DR KEGG; mmu:114570; -.
DR UCSC; uc008cst.1; mouse.
DR UCSC; uc008csu.1; mouse. [Q6Q6R3-2]
DR CTD; 401262; -.
DR MGI; MGI:2152434; Crip3.
DR VEuPathDB; HostDB:ENSMUSG00000023968; -.
DR eggNOG; KOG1700; Eukaryota.
DR HOGENOM; CLU_054591_2_0_1; -.
DR InParanoid; Q6Q6R3; -.
DR OMA; RCEKPVF; -.
DR OrthoDB; 1214165at2759; -.
DR PhylomeDB; Q6Q6R3; -.
DR TreeFam; TF313758; -.
DR BioGRID-ORCS; 114570; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tbpl1; mouse.
DR PRO; PR:Q6Q6R3; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6Q6R3; protein.
DR Bgee; ENSMUSG00000023968; Expressed in thymus and 145 other tissues.
DR ExpressionAtlas; Q6Q6R3; baseline and differential.
DR Genevisible; Q6Q6R3; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042098; P:T cell proliferation; IMP:MGI.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; LIM domain; Metal-binding;
KW Reference proteome; Repeat; Zinc.
FT CHAIN 1..204
FT /note="Cysteine-rich protein 3"
FT /id="PRO_0000225639"
FT DOMAIN 3..64
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 122..183
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 88..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 186..204
FT /note="VNIGDVGCYIYDPVDIRSK -> GQSDPRHWTYENVWTTSLVVRHLDPSPIP
FT SDLHPLANKALGDRALSFRCEHWRCGLLHL (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:15380775"
FT /id="VSP_061232"
FT VAR_SEQ 186..204
FT /note="VNIGDVGCYIYDPVDIRSK -> GQSDPRHWTYENVWTTSLVV (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11713292,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_061233"
FT CONFLICT 110
FT /note="G -> R (in Ref. 1; AAK60925/AAK60926/AAK60525/
FT AAK60524, 2; AAS66891, 3; BAC37863 and 5; AAI16361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22611 MW; 814BE2746C333C74 CRC64;
MSWTCPRCQQ PVYFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA
LFGPRGVNIG GVGCYLYNLP TPPPASRISL SPSNFSPPRP RTGLSRAKKG PPYLKTFTGE
TSLCPGCGDP VFFAEKVMSL GRNWHRPCLR CQRCRKTLTA GSHAEHDGMP YCHIPCYGYL
FGPKGVNIGD VGCYIYDPVD IRSK
