ID   CRIPT_BOVIN             Reviewed;         101 AA.
AC   Q3ZC66;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Cysteine-rich PDZ-binding protein;
DE   AltName: Full=Cysteine-rich interactor of PDZ three;
DE            Short=Cysteine-rich interactor of PDZ3;
GN   Name=CRIPT;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH DLG4.
RX   PubMed=17474715; DOI=10.1021/bi062088k;
RA   Saro D., Li T., Rupasinghe C., Paredes A., Caspers N., Spaller M.R.;
RT   "A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from
RT   the mammalian neuronal protein PSD-95.";
RL   Biochemistry 46:6340-6352(2007).
CC   -!- FUNCTION: Involved in the cytoskeletal anchoring of DLG4 in excitatory
CC       synapses. {ECO:0000250|UniProtKB:Q792Q4}.
CC   -!- SUBUNIT: Interacts with TUBB1. Interacts strongly with the PDZ3 domain
CC       of members of the DLG4 family. Associates with microtubules (By
CC       similarity). Interacts with DLG4. {ECO:0000250,
CC       ECO:0000269|PubMed:17474715}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Synapse {ECO:0000250}.
CC       Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with
CC       DLG4 in asymmetric synapses. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRIPT family. {ECO:0000305}.
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DR   EMBL; BC102887; AAI02888.1; -; mRNA.
DR   RefSeq; NP_001029975.1; NM_001034803.2.
DR   AlphaFoldDB; Q3ZC66; -.
DR   SMR; Q3ZC66; -.
DR   STRING; 9913.ENSBTAP00000020872; -.
DR   PaxDb; Q3ZC66; -.
DR   PRIDE; Q3ZC66; -.
DR   Ensembl; ENSBTAT00000020872; ENSBTAP00000020872; ENSBTAG00000015723.
DR   GeneID; 617723; -.
DR   KEGG; bta:617723; -.
DR   CTD; 9419; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015723; -.
DR   VGNC; VGNC:27712; CRIPT.
DR   eggNOG; KOG3476; Eukaryota.
DR   GeneTree; ENSGT00950000183100; -.
DR   HOGENOM; CLU_133934_0_0_1; -.
DR   InParanoid; Q3ZC66; -.
DR   OMA; KTGFAIC; -.
DR   OrthoDB; 1599604at2759; -.
DR   TreeFam; TF300144; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000015723; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0043198; C:dendritic shaft; ISS:UniProtKB.
DR   GO; GO:0043197; C:dendritic spine; ISS:UniProtKB.
DR   GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0008017; F:microtubule binding; ISS:CAFA.
DR   GO; GO:0030165; F:PDZ domain binding; ISS:UniProtKB.
DR   GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:UniProtKB.
DR   GO; GO:0045184; P:establishment of protein localization; ISS:UniProtKB.
DR   GO; GO:0035372; P:protein localization to microtubule; ISS:CAFA.
DR   GO; GO:1902897; P:regulation of postsynaptic density protein 95 clustering; ISS:CAFA.
DR   InterPro; IPR019367; PDZ-binding_CRIPT.
DR   PANTHER; PTHR11805; PTHR11805; 1.
DR   Pfam; PF10235; Cript; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cytoplasm; Reference proteome; Synapse.
FT   CHAIN           1..101
FT                   /note="Cysteine-rich PDZ-binding protein"
FT                   /id="PRO_0000314562"
FT   REGION          95..101
FT                   /note="Sufficient for interaction with DLG4"
FT                   /evidence="ECO:0000269|PubMed:17474715"
FT   REGION          98..101
FT                   /note="PDZ3-binding"
SQ   SEQUENCE   101 AA;  11216 MW;  161B0F4CA87DFBAD CRC64;
     MVCEKCEKKL GTVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY GKNKFSTCRI
     CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS V