ID   CRISA_XENTR             Reviewed;         204 AA.
AC   F7C0L1;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 2.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Allurin;
DE   AltName: Full=Cysteine-rich secretory protein A;
DE            Short=CRISP-A;
DE   Flags: Precursor;
GN   Name=crisp-a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   FUNCTION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18342304; DOI=10.1016/j.ydbio.2008.01.046;
RA   Burnett L.A., Boyles S., Spencer C., Bieber A.L., Chandler D.E.;
RT   "Xenopus tropicalis allurin: expression, purification, and characterization
RT   of a sperm chemoattractant that exhibits cross-species activity.";
RL   Dev. Biol. 316:408-416(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Involved in sperm chemoattraction.
CC       {ECO:0000269|PubMed:18342304}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}. Secreted
CC       {ECO:0000269|PubMed:18342304}.
CC   -!- TISSUE SPECIFICITY: Expressed only in oviduct.
CC       {ECO:0000269|PubMed:18342304}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAMC01024493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01024494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01024495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001188271.1; NM_001201342.1.
DR   AlphaFoldDB; F7C0L1; -.
DR   SMR; F7C0L1; -.
DR   STRING; 8364.ENSXETP00000024385; -.
DR   GeneID; 100495843; -.
DR   KEGG; xtr:100495843; -.
DR   CTD; 100495843; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   InParanoid; F7C0L1; -.
DR   OrthoDB; 1528782at2759; -.
DR   TreeFam; TF316148; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; IDA:UniProtKB.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Secreted; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..204
FT                   /note="Allurin"
FT                   /id="PRO_0000418885"
FT   TRANSMEM        140..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..138
FT                   /note="SCP"
SQ   SEQUENCE   204 AA;  22655 MW;  83D311FE374F0874 CRC64;
     MDTFNFIICI SALFHSTYGD DGGTPMLDTE TQNYLVDLHN LLRRSVDPTA KDMLKMEWSP
     GAALNAQNAA AKCVMQHSSA TERQIQDPFN YVCGENIYVT TAKPDWAAAV NSWFNERNDF
     TYGVGPNSDK MIGHYTQVAW AKTYLLGCGL AFCPGNYYPY VSICHYCPMG NMINSIKTPY
     EAGEWCASCP ESCEDKLCTS NPTA