CRLB_DICDI
ID CRLB_DICDI Reviewed; 442 AA.
AC Q6UUW5; Q54HK6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Cyclic AMP receptor-like protein B;
GN Name=crlB; ORFNames=DDB_G0289395;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=14732403; DOI=10.1016/j.ydbio.2003.09.035;
RA Raisley B., Zhang M., Hereld D., Hadwiger J.A.;
RT "A cAMP receptor-like G protein-coupled receptor with roles in growth
RT regulation and development.";
RL Dev. Biol. 265:433-445(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- FUNCTION: Receptor for cAMP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Only detected in post-aggregative developmental
CC stages, peaking after 16 hours of starvation.
CC {ECO:0000269|PubMed:14732403}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 5 family.
CC {ECO:0000305}.
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DR EMBL; AY360136; AAQ63681.1; -; Genomic_DNA.
DR EMBL; AAFI02000140; EAL62725.1; -; Genomic_DNA.
DR RefSeq; XP_636227.1; XM_631135.1.
DR AlphaFoldDB; Q6UUW5; -.
DR SMR; Q6UUW5; -.
DR STRING; 44689.DDB0191394; -.
DR PaxDb; Q6UUW5; -.
DR EnsemblProtists; EAL62725; EAL62725; DDB_G0289395.
DR GeneID; 8627115; -.
DR KEGG; ddi:DDB_G0289395; -.
DR dictyBase; DDB_G0289395; crlB.
DR eggNOG; ENOG502RDFX; Eukaryota.
DR HOGENOM; CLU_620281_0_0_1; -.
DR InParanoid; Q6UUW5; -.
DR OMA; CITARAT; -.
DR PhylomeDB; Q6UUW5; -.
DR PRO; PR:Q6UUW5; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; ISS:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR GO; GO:0001646; F:cAMP receptor activity; ISS:dictyBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000848; GPCR_cAMP.
DR PRINTS; PR00247; GPCRCAMP.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..442
FT /note="Cyclic AMP receptor-like protein B"
FT /id="PRO_0000327675"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..255
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..334
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..410
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 432..442
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 83..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 50695 MW; CC101BF378B44704 CRC64;
MGGDIHLCSM ILGKNHLIFL YFANLFGSTL SFLATIITIV FYLVKKYIQN KSFRENPHQY
CHQHQYFDSS KLNEINNSGV GSYSSTPISI QNNNNKNNNL PKQKNNEKQP LINKNHNNYC
NYSTSATSSS SSSSSFSSTN SGSSYEYQQP QKNQQTLSSS DKNNTIPSTN TKYEIELSIP
QFKGNKCGPN CLLFSNIPQI KNALEQKKNP KKIDTLIFYL SISDFIAVSG IIIEQLIIIF
NKEISKSIGF CIGERVSIHF GLLATLFWSN CIAYYLLRET YELKPYNIRF VYFHIVCWGM
ALIGVASLFF SKIITVSNID QGGSWCSVSS SYQLYFWVIP LFVSFTWNLI CYCLIYRKFN
KIIGIYGIQS VQIKTIIIRK LSFYLLAFLI TWVWDVINNS IFLYEGKCPP FALWILQEFF
SSGYGFFNSL AYAVTTRFYS RK
