CRLC_DICDI
ID CRLC_DICDI Reviewed; 361 AA.
AC Q6UUW6; Q54QS8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Cyclic AMP receptor-like protein C;
GN Name=crlC; ORFNames=DDB_G0283619;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14732403; DOI=10.1016/j.ydbio.2003.09.035;
RA Raisley B., Zhang M., Hereld D., Hadwiger J.A.;
RT "A cAMP receptor-like G protein-coupled receptor with roles in growth
RT regulation and development.";
RL Dev. Biol. 265:433-445(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- FUNCTION: Receptor for cAMP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Present in growing cells but is undetectable after
CC 4 hours of starvation.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 5 family.
CC {ECO:0000305}.
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DR EMBL; AY360135; AAQ63680.1; -; Genomic_DNA.
DR EMBL; AAFI02000056; EAL65576.1; -; Genomic_DNA.
DR RefSeq; XP_638945.1; XM_633853.1.
DR AlphaFoldDB; Q6UUW6; -.
DR PaxDb; Q6UUW6; -.
DR EnsemblProtists; EAL65576; EAL65576; DDB_G0283619.
DR GeneID; 8624184; -.
DR KEGG; ddi:DDB_G0283619; -.
DR dictyBase; DDB_G0283619; crlC.
DR eggNOG; ENOG502QY50; Eukaryota.
DR HOGENOM; CLU_768205_0_0_1; -.
DR InParanoid; Q6UUW6; -.
DR OMA; FWTTCIS; -.
DR PhylomeDB; Q6UUW6; -.
DR PRO; PR:Q6UUW6; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; ISS:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR GO; GO:0001646; F:cAMP receptor activity; ISS:dictyBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000848; GPCR_cAMP.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PRINTS; PR00247; GPCRCAMP.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..361
FT /note="Cyclic AMP receptor-like protein C"
FT /id="PRO_0000327676"
FT TOPO_DOM 1..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..318
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..361
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 361 AA; 41278 MW; B50024E6A762E759 CRC64;
MGIEESQICN PSDREFLSVD ILNIVTSSLS LMGSALTIIS YIWKKVRRHR IQKQQIQQQQ
QQIEKGGLLS SSITIGNGSS HYGGIGGGGG SGNGTGIGAI GGPHGTYKQP TSKLPLLIFM
LSIADFFTSF FIIISQSYLI NNSKSYSTPY SPDLKIHFSP CIILRAIIQF FFLSTFFWTT
CISYYLFHQL SSPGEEKYLL AIFNVVSWGI PFAISMVITM TNSIVVNSDG WCEVAKPMEL
SLWFLPLFLC LLVCSIYYFR LRRLFRSKFE YRLQINDRLK QLDSTISRRL TLYIVVFVIC
WLPDVIQHFI SFFSKCTFFP LLILQNILTP SQGFWNFWIY SYTNKIARFT PSNDENKRLL
Q
