ID   CRLD1_CHICK             Reviewed;         523 AA.
AC   Q98ST5;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Cysteine-rich secretory protein LCCL domain-containing 1;
DE   AltName: Full=CocoaCrisp;
DE   Flags: Precursor;
GN   Name=CRISPLD1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Smith D.M., Collins-Racie L.A., Lavallie E.R., Gamer L., Roberts D.J.,
RA   Marigo V.A., Copeland N.G., Jenkins N.A., McCoy J., Tabin C.J.;
RT   "A novel cysteine-rich secreted protein (CRISP) family member, CocoaCrisp,
RT   provides insight into the process of septation in the developing chicken
RT   midbrain.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; AF329199; AAK16497.1; -; mRNA.
DR   AlphaFoldDB; Q98ST5; -.
DR   SMR; Q98ST5; -.
DR   STRING; 9031.ENSGALP00000035874; -.
DR   PaxDb; Q98ST5; -.
DR   VEuPathDB; HostDB:geneid_395369; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   InParanoid; Q98ST5; -.
DR   OrthoDB; 1528782at2759; -.
DR   PhylomeDB; Q98ST5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   Gene3D; 2.170.130.20; -; 2.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   Pfam; PF03815; LCCL; 2.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00603; LCCL; 2.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   SUPFAM; SSF69848; SSF69848; 2.
DR   PROSITE; PS01010; CRISP_2; 1.
DR   PROSITE; PS50820; LCCL; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..523
FT                   /note="Cysteine-rich secretory protein LCCL domain-
FT                   containing 1"
FT                   /id="PRO_0000248148"
FT   DOMAIN          66..206
FT                   /note="SCP"
FT   DOMAIN          302..397
FT                   /note="LCCL 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DOMAIN          403..505
FT                   /note="LCCL 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   REGION          246..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        308..326
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        330..350
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        409..431
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        435..458
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
SQ   SEQUENCE   523 AA;  59050 MW;  3AF283C19DC3C55F CRC64;
     MKYVVQEWLR ITTLLFIAQA VSAMVLPNAT LLEELLEKYM DEDGEWWIAN VSRKRAITDS
     DMQSILDLHN KLRGQVYPPA SNMEYMTWDT ELERSAESWA ETCLWEHGPA SLLPSIGQNL
     GAHWGRYRPP TFHVQAWYDE VRDFTYPHPH ECNPYCPYKC SGPVCTHYTQ VVWATSSRIG
     CAINLCHNMN IWGQIWPKAV YLVCNYSPKG NWWGHAPYKP GRPCSACPPS FGGGCRENLC
     YREGSERPYS PHEPEEETNE IERQRSKAQD ATAQSRPRTH SPSGSTGSED SEKNEVISTQ
     QMSQIVSCEV RLRDQCKGTT CNRYECPAGC LDSKAKVIGS VHYEMQSSIC KAAIHYGILD
     NEGGWVDVTR QGRKNYFIKS YRNGIQSIGK YQSANSFTVS KVTVQAITCE TTVEQLCPFQ
     KPASHCPRVY CPHNCMQANP HYARVIGTRI YSDISSICRA AVHAGVVRNE GGYVDVMPVD
     KRKVYIASFL NGIFSESLQN PPGKQGIQSI CCRLNQVDYK TGK