CRLD1_MOUSE
ID CRLD1_MOUSE Reviewed; 500 AA.
AC Q8CGD2; Q8K018; Q99MM6;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Cysteine-rich secretory protein LCCL domain-containing 1;
DE AltName: Full=CocoaCrisp;
DE Flags: Precursor;
GN Name=Crispld1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Smith D.M., Collins-Racie L.A., Lavallie E.R., Gamer L., Roberts D.J.,
RA Marigo V.A., Copeland N.G., Jenkins N.A., McCoy J., Tabin C.J.;
RT "A novel cysteine-rich secreted protein (CRISP) family member, CocoaCrisp,
RT provides insight into the process of septation in the developing chicken
RT midbrain.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, Embryo, Fetal liver, and Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK16496.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF329198; AAK16496.1; ALT_FRAME; mRNA.
DR EMBL; AK132405; BAE21150.1; -; mRNA.
DR EMBL; AK133870; BAE21900.1; -; mRNA.
DR EMBL; AK134273; BAE22076.1; -; mRNA.
DR EMBL; AK137611; BAE23431.1; -; mRNA.
DR EMBL; BC034334; AAH34334.1; -; mRNA.
DR EMBL; BC040768; AAH40768.1; -; mRNA.
DR CCDS; CCDS35519.1; -.
DR RefSeq; NP_113579.2; NM_031402.2.
DR RefSeq; XP_006495655.1; XM_006495592.3.
DR RefSeq; XP_006495656.1; XM_006495593.3.
DR AlphaFoldDB; Q8CGD2; -.
DR SMR; Q8CGD2; -.
DR STRING; 10090.ENSMUSP00000092686; -.
DR iPTMnet; Q8CGD2; -.
DR PhosphoSitePlus; Q8CGD2; -.
DR PaxDb; Q8CGD2; -.
DR PRIDE; Q8CGD2; -.
DR ProteomicsDB; 283957; -.
DR Antibodypedia; 12356; 90 antibodies from 18 providers.
DR DNASU; 83691; -.
DR Ensembl; ENSMUST00000095075; ENSMUSP00000092686; ENSMUSG00000025776.
DR Ensembl; ENSMUST00000159958; ENSMUSP00000124095; ENSMUSG00000025776.
DR GeneID; 83691; -.
DR KEGG; mmu:83691; -.
DR UCSC; uc007akg.1; mouse.
DR CTD; 83690; -.
DR MGI; MGI:1934666; Crispld1.
DR VEuPathDB; HostDB:ENSMUSG00000025776; -.
DR eggNOG; KOG3017; Eukaryota.
DR GeneTree; ENSGT00940000156473; -.
DR HOGENOM; CLU_042287_0_0_1; -.
DR InParanoid; Q8CGD2; -.
DR OMA; DGEWWMA; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q8CGD2; -.
DR TreeFam; TF316148; -.
DR BioGRID-ORCS; 83691; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8CGD2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8CGD2; protein.
DR Bgee; ENSMUSG00000025776; Expressed in humerus cartilage element and 204 other tissues.
DR ExpressionAtlas; Q8CGD2; baseline and differential.
DR Genevisible; Q8CGD2; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0060325; P:face morphogenesis; ISO:MGI.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI.
DR Gene3D; 2.170.130.20; -; 2.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR Pfam; PF03815; LCCL; 2.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00603; LCCL; 2.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR SUPFAM; SSF69848; SSF69848; 2.
DR PROSITE; PS01010; CRISP_2; 1.
DR PROSITE; PS50820; LCCL; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..500
FT /note="Cysteine-rich secretory protein LCCL domain-
FT containing 1"
FT /id="PRO_0000248147"
FT DOMAIN 66..206
FT /note="SCP"
FT DOMAIN 289..384
FT /note="LCCL 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT DOMAIN 390..492
FT /note="LCCL 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT REGION 258..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 295..313
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT DISULFID 317..337
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT DISULFID 396..418
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT DISULFID 422..445
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT CONFLICT 10..11
FT /note="RV -> KM (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="N -> K (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
FT CONFLICT 51..53
FT /note="QRG -> PRR (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="Q -> H (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="Y -> N (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
FT CONFLICT 448..449
FT /note="AV -> LL (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
FT CONFLICT 487
FT /note="N -> T (in Ref. 1; AAK16496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 56918 MW; 6F740A627739EF6D CRC64;
MMCKAQEWLR VTALLFVARA VPAMVVPNAT LLEKLLEKYM DEDGEWWTAK QRGKRAITDN
DMQSILDLHN KLRSQVYPTA SNMEYMTWDV ELERSAESWA EMCLWEHGPA SLLPSIGQNL
GAHWGRYRPP TFHVQAWYDE VRDFSYPYEN ECDPYCPFRC SGPVCTHYTQ VVWATSSRIG
CAVNLCHNMN IWGQIWPKAV YLVCNYSPKG NWWGHAPYKH GRPCSACPPS FGGGCRENLC
YKEGSDRYYT PREEETNEIE RQQSQVHDTH VRTRSDDSDR NDVISTQQMS QIVSCEVRLR
DQCKGTTCNR YECPAGCLDS KAKVIGSVHY EMQSSICRAA IHYGIIDNEG GWVDVTRQGR
KHYFIKSNRN GIQTIGKYHS ANSFTVSKVT VQAVTCETTV EQLCPFHKPA SHCPRVYCPR
NCMQSNPHYA RVIGTRIYSD LSSICRAAVH AGVVRNHGGY VDVMPVDKRK MYTASFQNGI
FSESLQNPTG GKAFRVFAVV
