ID   CRLD2_XENTR             Reviewed;         500 AA.
AC   Q4V9Y5;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Cysteine-rich secretory protein LCCL domain-containing 2;
DE   Flags: Precursor;
GN   Name=crispld2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes matrix assembly. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; BC096629; AAH96629.1; -; mRNA.
DR   RefSeq; NP_001027499.1; NM_001032328.1.
DR   AlphaFoldDB; Q4V9Y5; -.
DR   SMR; Q4V9Y5; -.
DR   Ensembl; ENSXETT00000029363; ENSXETP00000029363; ENSXETG00000013394.
DR   GeneID; 613091; -.
DR   KEGG; xtr:613091; -.
DR   CTD; 83716; -.
DR   Xenbase; XB-GENE-985953; crispld2.
DR   HOGENOM; CLU_042287_0_0_1; -.
DR   InParanoid; Q4V9Y5; -.
DR   OrthoDB; 1528782at2759; -.
DR   PhylomeDB; Q4V9Y5; -.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013394; Expressed in skeletal muscle tissue and 5 other tissues.
DR   ExpressionAtlas; Q4V9Y5; differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005539; F:glycosaminoglycan binding; IBA:GO_Central.
DR   Gene3D; 2.170.130.20; -; 2.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR004043; LCCL.
DR   InterPro; IPR036609; LCCL_sf.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   Pfam; PF03815; LCCL; 2.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00603; LCCL; 2.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   SUPFAM; SSF69848; SSF69848; 2.
DR   PROSITE; PS01010; CRISP_2; 1.
DR   PROSITE; PS50820; LCCL; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..500
FT                   /note="Cysteine-rich secretory protein LCCL domain-
FT                   containing 2"
FT                   /id="PRO_0000248150"
FT   DOMAIN          62..201
FT                   /note="SCP"
FT   DOMAIN          287..382
FT                   /note="LCCL 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DOMAIN          388..491
FT                   /note="LCCL 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   REGION          260..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        293..311
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        315..335
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        394..416
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
FT   DISULFID        420..443
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00123"
SQ   SEQUENCE   500 AA;  56541 MW;  DD0D50BD9BD6F273 CRC64;
     MSSAMNWILS LGLFFLLKEQ CYCIFAPNST FLENLLNKYK DTTPHSRTRR AILRTDKEEI
     IQLHNKLRGQ VHPSASNMEY MTWDDELEKS AEAWAEECIW EHGPTALLMS IGQNLAVHWG
     RYRQPAYHVQ SWYDEVKDYT YPYPHECNPY CPERCSGPMC THYTQIVWAT TTKVGCAVNV
     CKRMNVWGDI WENAVYLVCN YSPKGNWIGE APYKNGRPCS ECPPSYGGNC QNNLCYKGDK
     HYGREGIVTN EVETPRFPEE TPVWDHKKSN KPKAVPKTTQ TSTENLMTQA IKCATKMRDS
     CKGSTCNRYK CPPGCINSKA KVFGTLFYDS MSSICRAAIH YGVIDNSGGL VDITRKGRLQ
     FFVKSTRNSV ESISKFKPAN SFMVSKVSAQ TIDCYTTVAE ICQFVKPATH CPRFNCPAHC
     KNEPSYWAPV IGTNIYADSS SICKTAVHAG VIKDGEGGYV DVMPVEKKKH YFGSNKNGIQ
     SDSIQNHKEG QAFRIFAVKQ