CRLD_DICDI
ID CRLD_DICDI Reviewed; 470 AA.
AC Q54QV5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Cyclic AMP receptor-like protein D;
GN Name=crlD; ORFNames=DDB_G0283579;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
CC -!- FUNCTION: Receptor for cAMP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 5 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000055; EAL65667.1; -; Genomic_DNA.
DR RefSeq; XP_639029.1; XM_633937.1.
DR AlphaFoldDB; Q54QV5; -.
DR STRING; 44689.DDB0231823; -.
DR PaxDb; Q54QV5; -.
DR PRIDE; Q54QV5; -.
DR EnsemblProtists; EAL65667; EAL65667; DDB_G0283579.
DR GeneID; 8624157; -.
DR KEGG; ddi:DDB_G0283579; -.
DR dictyBase; DDB_G0283579; crlD.
DR eggNOG; ENOG502S5I8; Eukaryota.
DR HOGENOM; CLU_581951_0_0_1; -.
DR InParanoid; Q54QV5; -.
DR OMA; ISTFFWT; -.
DR PRO; PR:Q54QV5; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PRINTS; PR00237; GPCRRHODOPSN.
PE 3: Inferred from homology;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..470
FT /note="Cyclic AMP receptor-like protein D"
FT /id="PRO_0000371350"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..372
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..470
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 172..287
FT /evidence="ECO:0000250"
SQ SEQUENCE 470 AA; 52935 MW; 0CACEA692A40FB7C CRC64;
MSSCSSLSMD DRVKIGYGSI AGASLSIIGS IGTIILIKIR NKKQEKKLLI QRKQQLSINN
LNINSGSSSN IITISNSTTS LSSNNLNIQP PSFPSYSPLP TSISLSNNNN NNKNNNQKTK
VSHFIINLSI ANLLASIFMI TIKLMMIHFN DKFIKVLPST ANHSFNALIS VCTIGNGVIG
FSFISTFFWT LAISMYIYQQ FLSSSTINSN NNNNNINNIN NNNNNNINNI NNSKNNNSIN
NFNNSNKSNK IIKMLFYFVC WVIPFVLGSI LVSGSRLIEL NSDLPWCSID SNIQLISFYF
PLIICLLATT FFTILIKYKF SNDKLACSSS SLINLQSKII QRLILFLIVI LVCWVPSLIS
FFISFFSKNC KQFLWLEIIS STIQSCQGIL NFLSYLSIFK KLKLYFKNLK KKFNNNNSNN
SNNSNNNNSN NFNGGGIFYS KGKKVNNQNS NNFYFTFSTF DFDNNQIQEK
