CRLF2_RAT
ID CRLF2_RAT Reviewed; 360 AA.
AC Q8R4S8;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Cytokine receptor-like factor 2;
DE AltName: Full=Thymic stromal lymphopoietin protein receptor;
DE Short=TSLP receptor;
DE Flags: Precursor;
GN Name=Crlf2; Synonyms=Tslpr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION AS A RECEPTOR FOR TSLP, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain, and Spleen;
RX PubMed=11891057; DOI=10.1016/s0378-1119(02)00380-3;
RA Blagoev B., Nielsen M.M., Angrist M., Chakravarti A., Pandey A.;
RT "Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and
RT characterization of genomic structure of murine Tslpr gene.";
RL Gene 284:161-168(2002).
CC -!- FUNCTION: Receptor for thymic stromal lymphopoietin (TSLP). Forms a
CC functional complex with TSLP and IL7R which is capable of stimulating
CC cell proliferation through activation of STAT3 and STAT5 (By
CC similarity). Also activates JAK2 (By similarity). Implicated in the
CC development of the hematopoietic system. {ECO:0000250,
CC ECO:0000269|PubMed:11891057}.
CC -!- SUBUNIT: Heterodimer of CRLF2 and IL7R.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in all tissues examined including brain,
CC thymus, lung, heart, muscle, stomach, small intestine, liver, kidney,
CC spleen, testis and skin. Highest levels in thymus, liver and testis.
CC {ECO:0000269|PubMed:11891057}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
CC subfamily. {ECO:0000305}.
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DR EMBL; AF404510; AAL90454.1; -; mRNA.
DR AlphaFoldDB; Q8R4S8; -.
DR SMR; Q8R4S8; -.
DR STRING; 10116.ENSRNOP00000066370; -.
DR GlyGen; Q8R4S8; 3 sites.
DR PaxDb; Q8R4S8; -.
DR RGD; 621078; Crlf2.
DR eggNOG; ENOG502RYG2; Eukaryota.
DR InParanoid; Q8R4S8; -.
DR PhylomeDB; Q8R4S8; -.
DR PRO; PR:Q8R4S8; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IDA:RGD.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; TAS:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0032754; P:positive regulation of interleukin-5 production; ISO:RGD.
DR GO; GO:0033005; P:positive regulation of mast cell activation; ISO:RGD.
DR GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; ISO:RGD.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..360
FT /note="Cytokine receptor-like factor 2"
FT /id="PRO_0000011043"
FT TOPO_DOM 27..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 123..214
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT MOTIF 205..209
FT /note="WSXWS motif"
FT MOTIF 268..276
FT /note="Box 1 motif"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 77..90
FT /evidence="ECO:0000250|UniProtKB:Q8CII9"
FT DISULFID 185..223
FT /evidence="ECO:0000250|UniProtKB:Q8CII9"
SQ SEQUENCE 360 AA; 38445 MW; 767B1CE489768870 CRC64;
MRAVTWAIVA MLLPRVLGAI PTRTPRTGGV GDTLSVAIVC HDLESVEVTW GPGSAHHGLS
ANLSLEFRYG NQVPQPCPHY FLLDSVRAGC VLPMGKGLLE VVLREGGGAK LFSRKKKASA
WLRPRPPWNV TLSWVGDTVA VSCPSHSYPG LEYEVQHRDD FDPEWQSTSA PFCNLTVGGL
DPGRCYDFRV RATPQDFYYG PEARPSKWTG VASLQGVGPT GSCTGPTLPR TPGTPTPPLA
LACGLAVALL TLVLLLALLR MRRVKEALLP GVPDPRGSFP GLFEKHHGNF QAWIADSQAA
VPTVPEQDKD DDVIRPQTKG VETQEDDDVI APGSPCLGGG ALMSVGGASF LMGDSGYTTL
