ID   CRLF3_DANRE             Reviewed;         444 AA.
AC   Q568M3; A8Y6W7; Q5BLI0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Cytokine receptor-like factor 3;
DE            Short=Clf-3 protein;
GN   Name=crlf3; Synonyms=clf-3; ORFNames=zgc:110212;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17640376; DOI=10.1186/1471-2148-7-120;
RA   Liongue C., Ward A.C.;
RT   "Evolution of Class I cytokine receptors.";
RL   BMC Evol. Biol. 7:120-120(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the negative regulation of cell cycle
CC       progression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytokine receptor-like factor 3 family.
CC       {ECO:0000305}.
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DR   EMBL; AM233512; CAJ80719.1; -; mRNA.
DR   EMBL; BC090429; AAH90429.1; -; mRNA.
DR   EMBL; BC092800; AAH92800.1; -; mRNA.
DR   AlphaFoldDB; Q568M3; -.
DR   SMR; Q568M3; -.
DR   STRING; 7955.ENSDARP00000070383; -.
DR   PaxDb; Q568M3; -.
DR   ZFIN; ZDB-GENE-050417-354; crlf3.
DR   eggNOG; ENOG502QQI2; Eukaryota.
DR   InParanoid; Q568M3; -.
DR   PhylomeDB; Q568M3; -.
DR   PRO; PR:Q568M3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..444
FT                   /note="Cytokine receptor-like factor 3"
FT                   /id="PRO_0000288938"
FT   DOMAIN          177..270
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   COILED          1..65
FT                   /evidence="ECO:0000255"
FT   CONFLICT        49
FT                   /note="K -> E (in Ref. 1; CAJ80719)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        187
FT                   /note="R -> G (in Ref. 2; AAH90429)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="A -> D (in Ref. 1; CAJ80719)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        385
FT                   /note="V -> M (in Ref. 1; CAJ80719)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   444 AA;  49267 MW;  466E0D430E51E2C1 CRC64;
     MSIEAEALLQ EAKESIEAAQ NYRSELQQRL HGLSQARKQV RGSASQTRKA LQRHFQELQT
     AVSRLLIDRL NGLLQEVDNI ELDSVSPLDD CQKLIEHGVS TADELLREGE AAIRCSINET
     EDKLGSFTKK ALQIQLDSLP EVPSLVDVPC LSAQLDDSLL HMFRAHVARH GSVASHPPVQ
     IEELVERPGG VLVRWCKVDD DFSPQDYRLQ FRRSNSSQYE DAYIGKDTEF LVLHLDPHVD
     HLFRVCARGE GRTEWSPWSI PQTGYTTLAP HEWCPGVDGY ILSSRKNIAM RSDSSAPGHG
     GVLYSNSPTY FCGQTLTFKI TAAGQTDKRD SLGVCADSRT DTDSLQRDQA VCISTNGAVF
     VNGKEMTNQL PAITVGSSVT FDMEVVSLFP VNNNNPSDGG NFKLRVTIGS GNREVVFDWL
     LDQVLDSLFF GCSFTHPGWK VLVF