CRLF3_MOUSE
ID CRLF3_MOUSE Reviewed; 442 AA.
AC Q9Z2L7; Q5SYK6; Q91W21; Q9R262;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Cytokine receptor-like factor 3;
DE AltName: Full=Cytokine receptor-like molecule 9;
DE Short=CREME-9;
DE AltName: Full=Cytokine receptor-related factor 4;
GN Name=Crlf3; Synonyms=Creme9, Cytor4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T.,
RA Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.;
RT "An extended gap penalty scheme for profiles results in the discovery of a
RT novel cytokine receptor related transcript in an EST database.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Bone, Liver, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5-442 (ISOFORM 1).
RC TISSUE=Brain;
RA Maeda M., Nomura H.;
RT "Cloning of a novel cytokine receptor-like molecule.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in the negative regulation of cell cycle
CC progression. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Z2L7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Z2L7-2; Sequence=VSP_025847, VSP_025848;
CC -!- SIMILARITY: Belongs to the cytokine receptor-like factor 3 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI24764.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF046060; AAD02423.1; -; mRNA.
DR EMBL; AK037880; BAC29888.1; -; mRNA.
DR EMBL; AK137528; BAE23396.1; -; mRNA.
DR EMBL; AK146798; BAE27440.1; -; mRNA.
DR EMBL; AL591113; CAI24762.1; -; Genomic_DNA.
DR EMBL; AL591113; CAI24763.1; -; Genomic_DNA.
DR EMBL; AL591113; CAI24764.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC004780; AAH04780.1; -; mRNA.
DR EMBL; AF120152; AAD31759.1; -; mRNA.
DR CCDS; CCDS25126.1; -. [Q9Z2L7-1]
DR CCDS; CCDS70260.1; -. [Q9Z2L7-2]
DR RefSeq; NP_001264035.1; NM_001277106.1. [Q9Z2L7-2]
DR RefSeq; NP_061246.1; NM_018776.2. [Q9Z2L7-1]
DR PDB; 6RPX; X-ray; 1.61 A; A=174-442.
DR PDB; 6RPY; X-ray; 1.97 A; A=174-442.
DR PDB; 6RPZ; X-ray; 1.74 A; A=174-442.
DR PDBsum; 6RPX; -.
DR PDBsum; 6RPY; -.
DR PDBsum; 6RPZ; -.
DR AlphaFoldDB; Q9Z2L7; -.
DR SMR; Q9Z2L7; -.
DR BioGRID; 207644; 3.
DR IntAct; Q9Z2L7; 1.
DR STRING; 10090.ENSMUSP00000060028; -.
DR PhosphoSitePlus; Q9Z2L7; -.
DR EPD; Q9Z2L7; -.
DR MaxQB; Q9Z2L7; -.
DR PaxDb; Q9Z2L7; -.
DR PeptideAtlas; Q9Z2L7; -.
DR PRIDE; Q9Z2L7; -.
DR ProteomicsDB; 284022; -. [Q9Z2L7-1]
DR ProteomicsDB; 284023; -. [Q9Z2L7-2]
DR Antibodypedia; 1925; 127 antibodies from 23 providers.
DR DNASU; 54394; -.
DR Ensembl; ENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561. [Q9Z2L7-1]
DR Ensembl; ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561. [Q9Z2L7-2]
DR GeneID; 54394; -.
DR KEGG; mmu:54394; -.
DR UCSC; uc007kld.2; mouse. [Q9Z2L7-1]
DR UCSC; uc011yaq.2; mouse. [Q9Z2L7-2]
DR CTD; 51379; -.
DR MGI; MGI:1860086; Crlf3.
DR VEuPathDB; HostDB:ENSMUSG00000017561; -.
DR eggNOG; ENOG502QQI2; Eukaryota.
DR GeneTree; ENSGT00940000153469; -.
DR HOGENOM; CLU_057983_0_0_1; -.
DR InParanoid; Q9Z2L7; -.
DR OMA; CNNNEGG; -.
DR OrthoDB; 881161at2759; -.
DR PhylomeDB; Q9Z2L7; -.
DR TreeFam; TF328682; -.
DR BioGRID-ORCS; 54394; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Crlf3; mouse.
DR PRO; PR:Q9Z2L7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9Z2L7; protein.
DR Bgee; ENSMUSG00000017561; Expressed in peripheral lymph node and 244 other tissues.
DR ExpressionAtlas; Q9Z2L7; baseline and differential.
DR Genevisible; Q9Z2L7; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Cytoplasm;
KW Reference proteome.
FT CHAIN 1..442
FT /note="Cytokine receptor-like factor 3"
FT /id="PRO_0000288937"
FT DOMAIN 181..274
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT COILED 10..46
FT /evidence="ECO:0000255"
FT VAR_SEQ 321..344
FT /note="VETVGQPDRRDSIGVCAERQNGYE -> CSLCQWKRNDQSVACSYLWLHCHI
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025847"
FT VAR_SEQ 345..442
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025848"
FT STRAND 182..190
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 195..202
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 208..217
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 224..230
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 232..236
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 245..255
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 266..268
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 284..286
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 292..295
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 304..308
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 316..323
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 332..338
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 344..346
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 351..354
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 360..362
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 379..385
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 401..408
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 411..418
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 426..431
FT /evidence="ECO:0007829|PDB:6RPX"
FT STRAND 438..441
FT /evidence="ECO:0007829|PDB:6RPX"
SQ SEQUENCE 442 AA; 49559 MW; 537CBBE507DFA3E6 CRC64;
MKGAMEPEPE VLLQEARENV EAAQSYRREL GQRLQGLREA QRQIKESASQ TRDVLKQHFS
DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE HGVNTADDLV REGEIAILGG
IEEESDKLWN FTKKASHIQL DSLPEVPLLV DVPCLSAQLD DSILNIVKDH IFKHGTVASR
PPVQIEELIE KPGGIIVRWC KVDDDFTAQD YRLQFRKCTA NHFEDVYVGS ETEFIVLHID
PNVDYQFRVC ARGDGRQEWS PWSVPQTGHS TLVPHEWTTG FEGYSLSSRR NIALRNDAES
SGVLYSSAPT YFCGQTLTFR VETVGQPDRR DSIGVCAERQ NGYESLQRDQ AVCISTNGAV
FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TSNSHEGGNA KLRVTISSNN REVVFDWLLE
QACGPLYFGC SFFYPGWKVL VF
