ID   CRLF3_XENLA             Reviewed;         436 AA.
AC   Q7ZX59;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cytokine receptor-like factor 3;
GN   Name=crlf3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the negative regulation of cell cycle
CC       progression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytokine receptor-like factor 3 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC045226; AAH45226.1; -; mRNA.
DR   RefSeq; NP_001080600.1; NM_001087131.1.
DR   AlphaFoldDB; Q7ZX59; -.
DR   SMR; Q7ZX59; -.
DR   MaxQB; Q7ZX59; -.
DR   PRIDE; Q7ZX59; -.
DR   DNASU; 380292; -.
DR   GeneID; 380292; -.
DR   KEGG; xla:380292; -.
DR   CTD; 380292; -.
DR   Xenbase; XB-GENE-997456; crlf3.L.
DR   OMA; CNNNEGG; -.
DR   OrthoDB; 881161at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 380292; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..436
FT                   /note="Cytokine receptor-like factor 3"
FT                   /id="PRO_0000288939"
FT   DOMAIN          177..270
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   COILED          9..87
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   436 AA;  48937 MW;  3BE3CA3647D846AE CRC64;
     MEGEAGGTLM QEAWESIDAA RNYKNELQER MIALELARNQ IKESAAQTCH ALRQHFVDLK
     TAITKLLDER QETLLQEVSA IEQENIKPLD DCQKLLEQGV NTADDLLKEG EMAVSGIAGN
     NENLYNFTNK ALHNQLDSLP EVPSLVEVPC LSAQLDEIFL CVVRDHICKL GSVASRPPVQ
     IEELIERPGA ILVKWCKCDD DFVAQDYRLQ YRKNTASHFE DVYVGSESEF IVLQIDPNVD
     YQFRVCARGD GRQEWSPWSV LQTSRTTLVP HEWSTGYDGY SLSSRRNIAL RNDSVSHGVL
     YSKAATYLSG QTLTFRVETV GQMDKHDGIG VCVEQFDCES LQRDKAVCVS TSGAVYVNGK
     EMTNQLPPVS PGSTITFDME IMTLGQTNNE GPSQKRRVTI SSSNREVVFD WLLEQSCDSL
     YFGCSFVHPG WKVLVF