CRLS1_CAEEL
ID CRLS1_CAEEL Reviewed; 246 AA.
AC O01916; Q5F4V9;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Probable cardiolipin synthase (CMP-forming);
DE Short=CLS;
DE EC=2.7.8.41 {ECO:0000250|UniProtKB:Q9UJA2};
GN Name=crls-1; ORFNames=F23H11.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Catalyzes the synthesis of cardiolipin (CL)
CC (diphosphatidylglycerol) by specifically transferring a phosphatidyl
CC group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key
CC phospholipid in mitochondrial membranes and plays important roles in
CC maintaining the functional integrity and dynamics of mitochondria under
CC both optimal and stress conditions. {ECO:0000250|UniProtKB:Q9UJA2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-
CC diacyl-sn-glycerol = a cardiolipin + CMP + H(+);
CC Xref=Rhea:RHEA:32931, ChEBI:CHEBI:15378, ChEBI:CHEBI:58332,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; EC=2.7.8.41;
CC Evidence={ECO:0000250|UniProtKB:Q9UJA2};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O01916-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O01916-2; Sequence=VSP_015561;
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC family. {ECO:0000305}.
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DR EMBL; FO081212; CCD69951.1; -; Genomic_DNA.
DR EMBL; FO081212; CCD69952.1; -; Genomic_DNA.
DR PIR; T34067; T34067.
DR RefSeq; NP_001022546.1; NM_001027375.2.
DR RefSeq; NP_001022547.1; NM_001027376.4. [O01916-2]
DR AlphaFoldDB; O01916; -.
DR BioGRID; 49693; 1.
DR DIP; DIP-24911N; -.
DR STRING; 6239.F23H11.9a; -.
DR EPD; O01916; -.
DR PaxDb; O01916; -.
DR PeptideAtlas; O01916; -.
DR EnsemblMetazoa; F23H11.9a.1; F23H11.9a.1; WBGene00017763. [O01916-1]
DR EnsemblMetazoa; F23H11.9b.1; F23H11.9b.1; WBGene00017763. [O01916-2]
DR GeneID; 184910; -.
DR UCSC; F23H11.9b.1; c. elegans. [O01916-1]
DR CTD; 184910; -.
DR WormBase; F23H11.9a; CE09617; WBGene00017763; crls-1. [O01916-1]
DR WormBase; F23H11.9b; CE37763; WBGene00017763; crls-1. [O01916-2]
DR eggNOG; KOG1617; Eukaryota.
DR GeneTree; ENSGT00390000001607; -.
DR InParanoid; O01916; -.
DR OMA; KRFNMAS; -.
DR OrthoDB; 1169813at2759; -.
DR PhylomeDB; O01916; -.
DR BRENDA; 2.7.8.41; 1045.
DR Reactome; R-CEL-1482925; Acyl chain remodelling of PG.
DR Reactome; R-CEL-1483076; Synthesis of CL.
DR PRO; PR:O01916; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00017763; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:WormBase.
DR GO; GO:0008808; F:cardiolipin synthase activity; IMP:WormBase.
DR GO; GO:0043337; F:CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity; IEA:RHEA.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IMP:WormBase.
DR GO; GO:0046474; P:glycerophospholipid biosynthetic process; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:WormBase.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; IMP:WormBase.
DR Gene3D; 1.20.120.1760; -; 1.
DR InterPro; IPR000462; CDP-OH_P_trans.
DR InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR Pfam; PF01066; CDP-OH_P_transf; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Lipid biosynthesis; Lipid metabolism; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..246
FT /note="Probable cardiolipin synthase (CMP-forming)"
FT /id="PRO_0000056818"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015561"
SQ SEQUENCE 246 AA; 26781 MW; DCA311B75751CAAE CRC64;
MIVTSMFRGI ACRCELQLLL TPRRMLRNFS SLEQKQSPKI ESLPPEERGK YKVATIPNAI
CTARIAATPL IGYLVVQHNF TPAFVLFTVA GATDLLDGFI ARNVPGQKSL LGSVLDPVAD
KLLISTMFIT MTYAGLIPLP LTSVVILRDI CLIGGGFYKR YQVMSPPYSL SRFFNPQVSS
MQVVPTMMSK INTVLQITLV ALSLSSPVFD FSTGANDVIV GLGCITGFTT IYSGLQYASG
KAIKKI
