ID   CRL_SALCH               Reviewed;         133 AA.
AC   Q57ST5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   Name=crl {ECO:0000255|HAMAP-Rule:MF_01178}; OrderedLocusNames=SCH_0320;
OS   Salmonella choleraesuis (strain SC-B67).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase, activating
CC       expression of sigma-S-regulated genes. Stimulates RNA polymerase
CC       holoenzyme formation and may bind to several other sigma factors, such
CC       as sigma-70 and sigma-32. {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
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DR   EMBL; AE017220; AAX64226.1; -; Genomic_DNA.
DR   RefSeq; WP_011264201.1; NC_006905.1.
DR   AlphaFoldDB; Q57ST5; -.
DR   SMR; Q57ST5; -.
DR   EnsemblBacteria; AAX64226; AAX64226; SCH_0320.
DR   KEGG; sec:SCH_0320; -.
DR   HOGENOM; CLU_136773_0_0_6; -.
DR   OMA; FWGWWLE; -.
DR   Proteomes; UP000000538; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.310.230; -; 1.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   InterPro; IPR038208; Tscrpt_reg_Crl_sf.
DR   Pfam; PF07417; Crl; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Cytoplasm; Transcription; Transcription regulation.
FT   CHAIN           1..133
FT                   /note="Sigma factor-binding protein Crl"
FT                   /id="PRO_0000268901"
FT   REGION          99..122
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
FT   COILED          90..111
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
SQ   SEQUENCE   133 AA;  15799 MW;  1D014E615DAF7897 CRC64;
     MTLPSGHPKS RLIKKFTALG PYIREGQCED NRFFFDCLAV CVNVKPAPEK REFWGWWMEL
     EAQEKRFTYR YQFGLFDKEG NWTAVPINET EVVERLEYTL REFHEKLRDL LISMELTLEP
     SDDFNDEPVK LSA