CRL_SALTI
ID CRL_SALTI Reviewed; 133 AA.
AC Q8XH11; Q7ANI3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN Name=crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN OrderedLocusNames=STY0364, t2531;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
CC -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase, activating
CC expression of sigma-S-regulated genes. Stimulates RNA polymerase
CC holoenzyme formation and may bind to several other sigma factors, such
CC as sigma-70 and sigma-32. {ECO:0000255|HAMAP-Rule:MF_01178}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC Rule:MF_01178}.
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DR EMBL; AE014613; AAO70115.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD08789.1; -; Genomic_DNA.
DR RefSeq; NP_454931.1; NC_003198.1.
DR RefSeq; WP_000174696.1; NZ_WSUR01000017.1.
DR AlphaFoldDB; Q8XH11; -.
DR SMR; Q8XH11; -.
DR IntAct; Q8XH11; 1.
DR STRING; 220341.16501605; -.
DR EnsemblBacteria; AAO70115; AAO70115; t2531.
DR KEGG; stt:t2531; -.
DR KEGG; sty:STY0364; -.
DR PATRIC; fig|220341.7.peg.358; -.
DR eggNOG; ENOG502ZQ8E; Bacteria.
DR HOGENOM; CLU_136773_0_0_6; -.
DR OMA; FWGWWLE; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.310.230; -; 1.
DR HAMAP; MF_01178; Crl; 1.
DR InterPro; IPR009986; Tscrpt_reg_Crl.
DR InterPro; IPR038208; Tscrpt_reg_Crl_sf.
DR Pfam; PF07417; Crl; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Cytoplasm; Transcription; Transcription regulation.
FT CHAIN 1..133
FT /note="Sigma factor-binding protein Crl"
FT /id="PRO_0000268903"
FT REGION 99..122
FT /note="Essential for activity"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
FT COILED 90..111
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
SQ SEQUENCE 133 AA; 15797 MW; 0619C3D79FFF7897 CRC64;
MTLPSGHPKS RLIKKFTALG PYIREGQCED NRFFFDCLAV CVNVKPAPEK REFWGWWMEL
EAQEKRFTYR YQFGLFDKEG NWTVVPINET EVVERLEYTL REFHEKLRDL LISMELALEP
SDDFNDEPVK LSA
