ID   CRL_VIBCH               Reviewed;         129 AA.
AC   Q9KPT7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   Name=crl {ECO:0000255|HAMAP-Rule:MF_01178}; OrderedLocusNames=VC_2275;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase, activating
CC       expression of sigma-S-regulated genes. Stimulates RNA polymerase
CC       holoenzyme formation and may bind to several other sigma factors, such
CC       as sigma-70 and sigma-32. {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
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DR   EMBL; AE003852; AAF95419.1; -; Genomic_DNA.
DR   PIR; G82095; G82095.
DR   RefSeq; NP_231906.1; NC_002505.1.
DR   RefSeq; WP_001293331.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KPT7; -.
DR   SMR; Q9KPT7; -.
DR   STRING; 243277.VC_2275; -.
DR   DNASU; 2613197; -.
DR   EnsemblBacteria; AAF95419; AAF95419; VC_2275.
DR   GeneID; 57740897; -.
DR   KEGG; vch:VC_2275; -.
DR   PATRIC; fig|243277.26.peg.2170; -.
DR   eggNOG; ENOG502ZQ8E; Bacteria.
DR   HOGENOM; CLU_136773_1_0_6; -.
DR   OMA; FWGWWLE; -.
DR   BioCyc; VCHO:VC2275-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.310.230; -; 1.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   InterPro; IPR038208; Tscrpt_reg_Crl_sf.
DR   Pfam; PF07417; Crl; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..129
FT                   /note="Sigma factor-binding protein Crl"
FT                   /id="PRO_0000268909"
FT   REGION          99..119
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
SQ   SEQUENCE   129 AA;  14963 MW;  1C9A68E4A9DAF8DF CRC64;
     MSEMTKTPTH YRLLSTLKAM GPYLREGQCS ERFYLFDCLA SCVNDKKSPE KREFWGWWME
     LTQNEQEMSA CYHIGRYTLA GDWVAEAIPE SAQAEVNHTQ AEFHKKLVKT LRERFEISVT
     VSTESAPFA