ID   CRL_VIBCM               Reviewed;         129 AA.
AC   C3LQ47;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   Name=crl {ECO:0000255|HAMAP-Rule:MF_01178}; OrderedLocusNames=VCM66_2198;
OS   Vibrio cholerae serotype O1 (strain M66-2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=579112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M66-2;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase, activating
CC       expression of sigma-S-regulated genes. Stimulates RNA polymerase
CC       holoenzyme formation and may bind to several other sigma factors, such
CC       as sigma-70 and sigma-32. {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
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DR   EMBL; CP001233; ACP06499.1; -; Genomic_DNA.
DR   RefSeq; WP_001293331.1; NC_012578.1.
DR   AlphaFoldDB; C3LQ47; -.
DR   SMR; C3LQ47; -.
DR   EnsemblBacteria; ACP06499; ACP06499; VCM66_2198.
DR   GeneID; 57740897; -.
DR   KEGG; vcm:VCM66_2198; -.
DR   HOGENOM; CLU_136773_1_0_6; -.
DR   OMA; FWGWWLE; -.
DR   Proteomes; UP000001217; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.310.230; -; 1.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   InterPro; IPR038208; Tscrpt_reg_Crl_sf.
DR   Pfam; PF07417; Crl; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Transcription; Transcription regulation.
FT   CHAIN           1..129
FT                   /note="Sigma factor-binding protein Crl"
FT                   /id="PRO_1000164427"
FT   REGION          99..119
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
SQ   SEQUENCE   129 AA;  14963 MW;  1C9A68E4A9DAF8DF CRC64;
     MSEMTKTPTH YRLLSTLKAM GPYLREGQCS ERFYLFDCLA SCVNDKKSPE KREFWGWWME
     LTQNEQEMSA CYHIGRYTLA GDWVAEAIPE SAQAEVNHTQ AEFHKKLVKT LRERFEISVT
     VSTESAPFA