ID   CRL_VIBVY               Reviewed;         129 AA.
AC   Q7MN60;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   Name=crl {ECO:0000255|HAMAP-Rule:MF_01178}; OrderedLocusNames=VV0857;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase, activating
CC       expression of sigma-S-regulated genes. Stimulates RNA polymerase
CC       holoenzyme formation and may bind to several other sigma factors, such
CC       as sigma-70 and sigma-32. {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
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DR   EMBL; BA000037; BAC93621.1; -; Genomic_DNA.
DR   RefSeq; WP_011078431.1; NC_005139.1.
DR   AlphaFoldDB; Q7MN60; -.
DR   SMR; Q7MN60; -.
DR   STRING; 672.VV93_v1c07960; -.
DR   EnsemblBacteria; BAC93621; BAC93621; BAC93621.
DR   GeneID; 66964096; -.
DR   KEGG; vvy:VV0857; -.
DR   eggNOG; ENOG502ZQ8E; Bacteria.
DR   HOGENOM; CLU_136773_1_0_6; -.
DR   OMA; FWGWWLE; -.
DR   OrthoDB; 1914214at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.310.230; -; 1.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   InterPro; IPR038208; Tscrpt_reg_Crl_sf.
DR   Pfam; PF07417; Crl; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..129
FT                   /note="Sigma factor-binding protein Crl"
FT                   /id="PRO_0000268912"
FT   REGION          99..119
FT                   /note="Essential for activity"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01178"
SQ   SEQUENCE   129 AA;  15062 MW;  E957A46DB1C1CDDE CRC64;
     MSEVTNNPTH NRLLAKLRAM GPYLRDPQSK EGLYYFDCLS VCIDDRKSPE LREFWGWWME
     LEATEGGFTA NYHIGKYDVE GNWLDLAIPK NALEEVNKTQ NCFHLKLVKT LEENFQLSVA
     YHEQSVEFV