ID   CRMB_ASPFU              Reviewed;         462 AA.
AC   Q4WYN5;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Probable alcohol acetyltransferase crmB {ECO:0000303|PubMed:29844112};
DE            EC=2.3.1.- {ECO:0000305|PubMed:29844112};
DE   AltName: Full=Copper-responsive metabolite biosynthesis cluster protein A {ECO:0000303|PubMed:29844112};
GN   Name=crmB {ECO:0000303|PubMed:29844112}; ORFNames=AFUA_3G13680;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION, INDUCTION, AND PATHWAY.
RX   PubMed=29844112; DOI=10.1128/mbio.00785-18;
RA   Lim F.Y., Won T.H., Raffa N., Baccile J.A., Wisecaver J., Rokas A.,
RA   Schroeder F.C., Keller N.P.;
RT   "Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus
RT   fumigatus.";
RL   MBio 9:0-0(2018).
CC   -!- FUNCTION: Probable alcohol acetyltransferase; part of the crm gene
CC       cluster that mediates the biosynthesis of a yet unidentified copper-
CC       responsive metabolite. {ECO:0000269|PubMed:29844112}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis.
CC       {ECO:0000305|PubMed:29844112}.
CC   -!- INDUCTION: Expressed in copper depleted conditions via the regulation
CC       of the macA transcription factor. {ECO:0000269|PubMed:29844112}.
CC   -!- SIMILARITY: Belongs to the alcohol acetyltransferase FCK4 family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92218.1; -; Genomic_DNA.
DR   RefSeq; XP_754256.1; XM_749163.1.
DR   AlphaFoldDB; Q4WYN5; -.
DR   SMR; Q4WYN5; -.
DR   STRING; 746128.CADAFUBP00003476; -.
DR   EnsemblFungi; EAL92218; EAL92218; AFUA_3G13680.
DR   GeneID; 3512309; -.
DR   KEGG; afm:AFUA_3G13680; -.
DR   eggNOG; ENOG502RC91; Eukaryota.
DR   HOGENOM; CLU_024469_1_1_1; -.
DR   InParanoid; Q4WYN5; -.
DR   OMA; VSASCHH; -.
DR   OrthoDB; 997311at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IBA:GO_Central.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR010828; Atf2/Sli1-like.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   Pfam; PF07247; AATase; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..462
FT                   /note="Probable alcohol acetyltransferase crmB"
FT                   /id="PRO_0000445299"
SQ   SEQUENCE   462 AA;  50544 MW;  C1E08043183676A4 CRC64;
     MSKGKLEQVS AACHHLGFFN NAGLSAHYKL SESSSPAVAD LRGLVYAAAG DLLRKHRILF
     AIPVNEGTPN PHFACLPWID LRRSIAFLER SVPLASAAEE QDKELDAILE EQHNIDFQTD
     YGTLPFWRLI ILRSKGRNDF TASFIYHHAI GDGVSGLAFH KAFCNALEAA SSSTLPTDRA
     ENIIRPDENT VVLPPLEELH PMPISPRQPP LPTASPKEWT GASIHLPCKS RWASLYISPS
     ASNAFVQECK EMKLSVTSAL SSVVAAVLFD NLPSRVEALT CIIPVSVRPW LKLPPQVIDN
     AIGTYFDALR VRLTRAEQRS QDPSPVGIWC GARQVSRSIN AYLCDVSPSG EPYTSVAAFK
     TVPDVSAVFR STLGKPRDAA FEVTNVGLFP PAAIRRPSRW KAGNVLLSRS AAVPGAAVTV
     SVVTGRDGTM ALGFSWQEGV VEDGFMHRVR QGVWKYFEKY QS