ID   CRMB_CAMPS              Reviewed;         349 AA.
AC   P68637; Q8UYA7;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Soluble TNF receptor II;
DE   AltName: Full=Cytokine response-modifying protein B;
DE   Flags: Precursor;
GN   Name=CRMB1; OrderedLocusNames=CMP2L;
GN   and
GN   Name=CRMB2; OrderedLocusNames=CMP205R;
OS   Camelpox virus (strain CMS).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203172;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11907336; DOI=10.1099/0022-1317-83-4-855;
RA   Gubser C., Smith G.L.;
RT   "The sequence of camelpox virus shows it is most closely related to variola
RT   virus, the cause of smallpox.";
RL   J. Gen. Virol. 83:855-872(2002).
CC   -!- FUNCTION: Receptor for TNF-alpha and TNF-beta. May contribute to the
CC       modification of TNF-mediated antiviral processes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AY009089; AAG37456.1; -; Genomic_DNA.
DR   EMBL; AY009089; AAG37718.1; -; Genomic_DNA.
DR   SMR; P68637; -.
DR   Proteomes; UP000107153; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR   CDD; cd15839; TNFRSF_viral; 1.
DR   InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR   InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR034059; TNFRSF_N_viral.
DR   Pfam; PF07190; DUF1406; 1.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   PIRSF; PIRSF001790; TNF_C22L; 1.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Receptor; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..349
FT                   /note="Soluble TNF receptor II"
FT                   /id="PRO_0000034617"
FT   REPEAT          31..65
FT                   /note="TNFR-Cys 1"
FT   REPEAT          67..108
FT                   /note="TNFR-Cys 2"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        248
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        32..43
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        44..57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        47..65
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        68..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        86..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        90..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   349 AA;  38065 MW;  EA412AF991E087F3 CRC64;
     MKSVLYSYIL FLSCIIINGR DVTPYAPSNG KCKDNEYKRH NLCCLSCPPG TYASRLCDSK
     TNTQCTPCGS GTFTSRNNHL PACLSCNGRC DSNQVETRSC NTTHNRICEC SPGYYCILKG
     SSGCKACVSQ TKCGIGYGVS GHTSAGDVIC SPCGLGTYSR TVSSADKCEP VPSNTFNYID
     VEINLYPVND TSCTRTTTTG ISESISTSEL TITMNHKDCD PVFREEYFSV LNKVATSGFF
     TGENRYQNIS KVCTLNFEIK CNNKGSSSKQ LTKAKNDDGI MPHSETVTLV GDCLSSVDIY
     ILYSNTNTQD YETDTISYHA GNVLDVDSHM PGSCDIHKLI TNSKPTHFL