ID   CRMB_CWPXG              Reviewed;         351 AA.
AC   O73559; P87602;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Soluble TNF receptor II;
DE   AltName: Full=Cytokine response-modifying protein B;
DE   Flags: Precursor;
GN   Name=CRMB1; ORFNames=D2L;
GN   and
GN   Name=CRMB2; ORFNames=I4R;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GRI-90 / Grishak;
RX   PubMed=9568042; DOI=10.1006/viro.1998.9039;
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A.,
RA   Ryazankina O.I., Gutorov V.V., Kotwal G.J.;
RT   "The genomic sequence analysis of the left and right species-specific
RT   terminal region of a cowpox virus strain reveals unique sequences and a
RT   cluster of intact ORFs for immunomodulatory and host range proteins.";
RL   Virology 243:432-460(1998).
RN   [2]
RP   FUNCTION.
RC   STRAIN=Brighton red;
RX   PubMed=8091665; DOI=10.1006/viro.1994.1539;
RA   Hu F.Q., Smith C.A., Pickup D.J.;
RT   "Cowpox virus contains two copies of an early gene encoding a soluble
RT   secreted form of the type II TNF receptor.";
RL   Virology 204:343-356(1994).
CC   -!- FUNCTION: Receptor for TNF-alpha and TNF-beta. May contribute to the
CC       modification of TNF-mediated antiviral processes.
CC       {ECO:0000269|PubMed:8091665}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; X94355; CAA64087.2; -; Genomic_DNA.
DR   EMBL; X94355; CAD90756.1; -; Genomic_DNA.
DR   SMR; O73559; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR   CDD; cd15839; TNFRSF_viral; 1.
DR   InterPro; IPR010806; Poxvirus_TNF-rcpt-II_C.
DR   InterPro; IPR011172; Poxvirus_TNF_rcpt-II.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR034059; TNFRSF_N_viral.
DR   Pfam; PF07190; DUF1406; 1.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   PIRSF; PIRSF001790; TNF_C22L; 1.
DR   SMART; SM00208; TNFR; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Receptor; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..351
FT                   /note="Soluble TNF receptor II"
FT                   /id="PRO_0000034618"
FT   REPEAT          31..67
FT                   /note="TNFR-Cys 1"
FT   REPEAT          69..110
FT                   /note="TNFR-Cys 2"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        191
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        250
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        32..43
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        44..57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        47..67
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        70..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        88..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        92..110
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   351 AA;  38254 MW;  57CAE73EF4E5D7C7 CRC64;
     MKSVLYSYIL FLSCIIINGR DIAPHAPSNG KCKDNEYNRH NLCCLSCPPG TYASRLCDSK
     TNTNTQCTPC GSGTFTSRNN HLPACLSCNG RCDSNQVETR SCNTTHNRIC ECAPGYYCLL
     KGSSGCKACV SQTKCGIGYG VSGHTSTGDV VCSPCGLGTY SHTVSSADKC EPVPSNTFNY
     IDVEINLYPV NDTSCTRTTT TGLSESISTS ELTITMNHKD CDPVFRDGYF SVLNKVATSG
     FFTGENRYQN ISKVCTLNFE IKCNNKDSSS KQLTKTKNDD GIMPHSETVT LVGDCLSSVD
     IYILYSNTNT QDYETDTISY HVGNVLDVDS HMPGSCDIHK LITNSKPTRF L