CRMC_ASPFU
ID CRMC_ASPFU Reviewed; 585 AA.
AC Q4WYN4;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Major facilitator copper-regulated transporter crmC {ECO:0000303|PubMed:29844112};
DE AltName: Full=Copper-responsive metabolite biosynthesis cluster protein C {ECO:0000303|PubMed:29844112};
GN Name=crmC {ECO:0000303|PubMed:29844112}; ORFNames=AFUA_3G13670;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29844112; DOI=10.1128/mbio.00785-18;
RA Lim F.Y., Won T.H., Raffa N., Baccile J.A., Wisecaver J., Rokas A.,
RA Schroeder F.C., Keller N.P.;
RT "Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus
RT fumigatus.";
RL MBio 9:0-0(2018).
CC -!- FUNCTION: Major facilitator copper-regulated transporter; part of the
CC crm gene cluster that mediates the biosynthesis of a yet unidentified
CC copper-responsive metabolite. {ECO:0000269|PubMed:29844112}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expressed in copper depleted conditions via the regulation
CC of the macA transcription factor. {ECO:0000269|PubMed:29844112}.
CC -!- DISRUPTION PHENOTYPE: Does not affect the xanthocillin production.
CC {ECO:0000269|PubMed:29844112}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AAHF01000002; EAL92219.1; -; Genomic_DNA.
DR RefSeq; XP_754257.1; XM_749164.1.
DR AlphaFoldDB; Q4WYN4; -.
DR SMR; Q4WYN4; -.
DR STRING; 746128.CADAFUBP00003477; -.
DR EnsemblFungi; EAL92219; EAL92219; AFUA_3G13670.
DR GeneID; 3512310; -.
DR KEGG; afm:AFUA_3G13670; -.
DR VEuPathDB; FungiDB:Afu3g13670; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_012970_1_0_1; -.
DR InParanoid; Q4WYN4; -.
DR OMA; KYECITA; -.
DR OrthoDB; 641071at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..585
FT /note="Major facilitator copper-regulated transporter crmC"
FT /id="PRO_0000445300"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 341
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 585 AA; 64583 MW; 0ED521D2A592D39B CRC64;
MAATTEKDLT ARTTANIEAA SDTVSLEEKS EREILERPNE ITQDAQIGVQ KAEATALVWS
KTALYATYAW IWVCFFILNL QFSISNNMIY YAYAGFSSAP QISQAYILST IIGGVLQLPI
AKTLNLWGRA EGFLVFVGVL IVGIIVIASC NGPNGFAAGY TLYWIGYTAV NFILVVFVAD
ASGLRNRAFA YAFIGTPTIC TAFVGPLAAQ AFYAHSTWRW AYGCFAIVIF FTFVPLALVF
KFYQRKAEKT GVFVRDPSGR TPLQSFRHYF REFDLVGAFL LMAAFVLFLL PFSLETYGFS
GYSSATFISM VVIGVLLFPV FAIWERFFAP TAFIKWQLFK NRTVLGACIL AAVIFFNYYT
WDQYYYYYLQ VVYNLNTANT GYMTQIYSVG STLWAVLFGI WIRQTKHFQK TCLYFGAPLM
LLGAGLMIHF RGAESKIGYL VMCQIFIAFG GGTLVIGDEM AVMAAADRDG VPMMIAMISL
AGSFGGAIGY AVAGAIYANT FPQALLRGLP DDLKGDSATV YLGGSTAQVM YPPGSAARNA
INHAWTESQK YECITATAVV VLAFPAIAMW KNYNVDRKQV KGTVI
