ID   CRMD_ASPFU              Reviewed;         218 AA.
AC   Q4WYN3;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Putative copper transporter crmD {ECO:0000303|PubMed:29844112};
DE   AltName: Full=Copper-responsive metabolite biosynthesis cluster protein D {ECO:0000303|PubMed:29844112};
GN   Name=crmD {ECO:0000303|PubMed:29844112}; ORFNames=AFUA_3G13660;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=29844112; DOI=10.1128/mbio.00785-18;
RA   Lim F.Y., Won T.H., Raffa N., Baccile J.A., Wisecaver J., Rokas A.,
RA   Schroeder F.C., Keller N.P.;
RT   "Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus
RT   fumigatus.";
RL   MBio 9:0-0(2018).
CC   -!- FUNCTION: Putative copper transporter; part of the crm gene cluster
CC       that mediates the biosynthesis of a yet unidentified copper-responsive
CC       metabolite (PubMed:29844112). Probably involved in the transport of
CC       copper (Probable). {ECO:0000269|PubMed:29844112,
CC       ECO:0000305|PubMed:29844112}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expressed in copper depleted conditions via the regulation
CC       of the macA transcription factor. {ECO:0000269|PubMed:29844112}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect the xanthocillin production.
CC       {ECO:0000269|PubMed:29844112}.
CC   -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC       SLC31A subfamily. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92220.1; -; Genomic_DNA.
DR   RefSeq; XP_754258.1; XM_749165.1.
DR   AlphaFoldDB; Q4WYN3; -.
DR   EnsemblFungi; EAL92220; EAL92220; AFUA_3G13660.
DR   GeneID; 3512311; -.
DR   KEGG; afm:AFUA_3G13660; -.
DR   VEuPathDB; FungiDB:Afu3g13660; -.
DR   eggNOG; ENOG502SQNR; Eukaryota.
DR   HOGENOM; CLU_081053_0_0_1; -.
DR   InParanoid; Q4WYN3; -.
DR   OMA; MNMPAVF; -.
DR   OrthoDB; 1335284at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 1.
PE   2: Evidence at transcript level;
KW   Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..218
FT                   /note="Putative copper transporter crmD"
FT                   /id="PRO_0000445301"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  24728 MW;  1C37A8C39A873633 CRC64;
     MHHNDHSNGM PMSMVFDTST EITLFFQGWT TTTAASYSLT LLFLFALAVF NRFLGVLKFQ
     LDVKHTQPTE GRVPKLQQPR ARRRHAIPKA RLSPQPRYMQ VAETDTEDEA PFSSAQFLES
     DAEHTRHEFP SDLIQEPQGP LGTRRWWNVY RRWSWRRDGT GSLLEGLRAL VGYALMLAVM
     TFNVGVLCAV VGGIVVGELL LGRYAQPSLG WQDDACHH