CRML_HUMAN
ID CRML_HUMAN Reviewed; 1269 AA.
AC Q96RY5; A8MZL1; B1AJY1; Q8NDN1; Q9P2C1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Protein cramped-like {ECO:0000305};
DE AltName: Full=Cramped chromatin regulator homolog 1 {ECO:0000312|HGNC:HGNC:14122};
DE AltName: Full=Hematological and neurological expressed 1-like protein;
GN Name=CRAMP1 {ECO:0000312|HGNC:HGNC:14122};
GN Synonyms=C16orf34, CRAMP1L, HN1L, KIAA1426;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-1269.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-1269.
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1268, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1268, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- SIMILARITY: Belongs to the cramped family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK61288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD38692.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AE006639; AAK61288.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL031009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL031708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z97652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL833832; CAD38692.1; ALT_SEQ; mRNA.
DR EMBL; AB037847; BAA92664.2; -; mRNA.
DR CCDS; CCDS10440.2; -.
DR RefSeq; NP_065876.3; NM_020825.3.
DR AlphaFoldDB; Q96RY5; -.
DR BioGRID; 121637; 31.
DR IntAct; Q96RY5; 18.
DR MINT; Q96RY5; -.
DR STRING; 9606.ENSP00000380559; -.
DR iPTMnet; Q96RY5; -.
DR PhosphoSitePlus; Q96RY5; -.
DR BioMuta; CRAMP1; -.
DR DMDM; 308153609; -.
DR EPD; Q96RY5; -.
DR jPOST; Q96RY5; -.
DR MassIVE; Q96RY5; -.
DR MaxQB; Q96RY5; -.
DR PaxDb; Q96RY5; -.
DR PeptideAtlas; Q96RY5; -.
DR PRIDE; Q96RY5; -.
DR ProteomicsDB; 78048; -.
DR Antibodypedia; 49822; 25 antibodies from 8 providers.
DR DNASU; 57585; -.
DR Ensembl; ENST00000293925.9; ENSP00000293925.5; ENSG00000007545.16.
DR Ensembl; ENST00000397412.8; ENSP00000380559.2; ENSG00000007545.16.
DR GeneID; 57585; -.
DR KEGG; hsa:57585; -.
DR MANE-Select; ENST00000397412.8; ENSP00000380559.2; NM_020825.4; NP_065876.3.
DR UCSC; uc010uvh.3; human.
DR CTD; 57585; -.
DR DisGeNET; 57585; -.
DR GeneCards; CRAMP1; -.
DR HGNC; HGNC:14122; CRAMP1.
DR HPA; ENSG00000007545; Low tissue specificity.
DR neXtProt; NX_Q96RY5; -.
DR OpenTargets; ENSG00000007545; -.
DR PharmGKB; PA26861; -.
DR VEuPathDB; HostDB:ENSG00000007545; -.
DR eggNOG; KOG4468; Eukaryota.
DR GeneTree; ENSGT00390000003337; -.
DR HOGENOM; CLU_003833_1_0_1; -.
DR InParanoid; Q96RY5; -.
DR OMA; ACSQLPD; -.
DR OrthoDB; 928654at2759; -.
DR PhylomeDB; Q96RY5; -.
DR TreeFam; TF328521; -.
DR PathwayCommons; Q96RY5; -.
DR SignaLink; Q96RY5; -.
DR BioGRID-ORCS; 57585; 92 hits in 1086 CRISPR screens.
DR ChiTaRS; CRAMP1; human.
DR GenomeRNAi; 57585; -.
DR Pharos; Q96RY5; Tdark.
DR PRO; PR:Q96RY5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96RY5; protein.
DR Bgee; ENSG00000007545; Expressed in thymus and 176 other tissues.
DR ExpressionAtlas; Q96RY5; baseline and differential.
DR Genevisible; Q96RY5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007389; P:pattern specification process; IBA:GO_Central.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR SMART; SM00717; SANT; 1.
DR PROSITE; PS51293; SANT; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1269
FT /note="Protein cramped-like"
FT /id="PRO_0000264471"
FT DOMAIN 161..224
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 1..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..73
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1268
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231"
FT CONFLICT 246
FT /note="G -> D (in Ref. 4; BAA92664)"
FT /evidence="ECO:0000305"
FT CONFLICT 503
FT /note="L -> S (in Ref. 4; BAA92664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1269 AA; 134718 MW; 16D630909A42618B CRC64;
MTVKLGDGGS GEDGLKKLGK RAADEESLEG EGAGGADAAE ESSGTKRDEK TPRAGADGPP
APPGAPQAPS PPQGSPQDQH HFLRSSVRPQ SKRPRKDPPS AVGSGNAGGS GPRGKGAEGG
GSSSGNVSGV APAAPAGGSR SSSRNLGSSG GEKEEGKKVR RQWESWSTED KNTFFEGLYE
HGKDFEAIQN NIALKYKKKG KPASMVKNKE QVRHFYYRTW HKITKYIDFD HVFSRGLKKS
SQELYGLICY GELRKKIGGC MDDKNATKLN ELIQVGATTV RYKGRNLRIK APMCRALKKL
CDPDGLSDEE DQKPVRLPLK VPIELQPRNN HAWARVQSLA QNPRLRMIVE LHRKVSSLIE
FLKQKWALHE VRVRKTLEER QLQDSCSAPM QEKVTLHLFP GENCTLTPLP GVARVVHSKA
FCTVHWQEGG RCKQSAKDAH VLPPAQILGI QSGQGTARGQ VKCPRSGAEG KGVGRPPPAA
DALQSSGESS PESAPGEGAA LSLSSPDAPD RPPPRHQDTG PCLEKTPAEG RDSPTREPGA
LPCACGQLPD LEDELSLLDP LPRYLKSCQD LIVPEQCRCA DTRPGSEQPP LGGAASPEVL
APVSKEAADL APTGPSPRPG PGLLLDVCTK DLADAPAEEL QEKGSPAGPP PSQGQPAARP
PKEVPASRLA QQLREEGWNL QTSESLTLAE VYLMMGKPSK LQLEYDWLGP GRQDPRPGSL
PTALHKQRLL SCLLKLISTE VNPKLALEAN TISTASVRPA QEEQSMTPPG KVVTVSSRSP
RCPRNQASLR SSKTFPPSSA PCSSGLRNPP RPLLVPGPSS TGSNDSDGGL FAVPTTLPPN
SRHGKLFSPS KEAELTFRQH LNSISMQSDF FLPKPRKLRN RHLRKPLVVQ RTLLPRPSEN
QSHNVCSFSI LSNSSVTGRG SFRPIQSSLT KAALSRPIVP KVLPPQATSH LASAIDLAAT
SAGILSGNPL PALDTEGLSG ISPLSSDEVT GAISGQDSTG THQDGDTLPT VGGSDPFVSI
PSRPEQEPVA DSFQGSSVLS LSELPKAPLQ NGLSIPLSSS ESSSTRLSPP DVSALLDISL
PGPPEDALSQ GEPATHISDS IIEIAISSGQ YGEGVPLSPA KLNGSDSSKS LPSPSSSPQP
HWIASPTHDP QWYPSDSTDS SLSSLFASFI SPEKSRKMLP TPIGTNSGTS LLGPSLLDGN
SRDSFVSRSL ADVAEVVDSQ LVCMMNENSI DYISRFNDLA QELSIAEPGR REALFDGGGG
GPAVSDLSQ
