CRML_MOUSE
ID CRML_MOUSE Reviewed; 1285 AA.
AC Q6PG95; E9QNA8; Q6ZPR3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein cramped-like {ECO:0000305};
DE AltName: Full=Cramped chromatin regulator homolog 1 {ECO:0000250|UniProtKB:Q96RY5};
DE AltName: Full=Hematological and neurological expressed 1-like protein;
GN Name=Cramp1 {ECO:0000250|UniProtKB:Q96RY5};
GN Synonyms=Cramp1l {ECO:0000312|MGI:MGI:1930190},
GN Hn1l {ECO:0000250|UniProtKB:Q96RY5},
GN Kiaa1426 {ECO:0000312|MGI:MGI:1930190}, Tce4 {ECO:0000312|MGI:MGI:1930190};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-1285.
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- SIMILARITY: Belongs to the cramped family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK147411; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK147411; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC154229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK129356; BAC98166.1; -; mRNA.
DR CCDS; CCDS50030.1; -.
DR RefSeq; NP_065633.2; NM_020608.3.
DR RefSeq; XP_006524765.1; XM_006524702.3.
DR RefSeq; XP_006524766.1; XM_006524703.3.
DR RefSeq; XP_017173078.1; XM_017317589.1.
DR AlphaFoldDB; Q6PG95; -.
DR BioGRID; 208268; 1.
DR STRING; 10090.ENSMUSP00000073060; -.
DR iPTMnet; Q6PG95; -.
DR PhosphoSitePlus; Q6PG95; -.
DR EPD; Q6PG95; -.
DR MaxQB; Q6PG95; -.
DR PaxDb; Q6PG95; -.
DR PeptideAtlas; Q6PG95; -.
DR PRIDE; Q6PG95; -.
DR ProteomicsDB; 277896; -.
DR Antibodypedia; 49822; 25 antibodies from 8 providers.
DR Ensembl; ENSMUST00000073337; ENSMUSP00000073060; ENSMUSG00000038002.
DR Ensembl; ENSMUST00000233774; ENSMUSP00000156906; ENSMUSG00000038002.
DR GeneID; 57354; -.
DR KEGG; mmu:57354; -.
DR UCSC; uc008azk.2; mouse.
DR CTD; 57585; -.
DR MGI; MGI:1930190; Cramp1.
DR VEuPathDB; HostDB:ENSMUSG00000038002; -.
DR eggNOG; KOG4468; Eukaryota.
DR GeneTree; ENSGT00390000003337; -.
DR HOGENOM; CLU_003833_1_0_1; -.
DR InParanoid; Q6PG95; -.
DR OMA; ACSQLPD; -.
DR OrthoDB; 928654at2759; -.
DR TreeFam; TF328521; -.
DR BioGRID-ORCS; 57354; 13 hits in 74 CRISPR screens.
DR ChiTaRS; Cramp1l; mouse.
DR PRO; PR:Q6PG95; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6PG95; protein.
DR Bgee; ENSMUSG00000038002; Expressed in rostral migratory stream and 255 other tissues.
DR ExpressionAtlas; Q6PG95; baseline and differential.
DR Genevisible; Q6PG95; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007389; P:pattern specification process; IBA:GO_Central.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR SMART; SM00717; SANT; 1.
DR PROSITE; PS51293; SANT; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1285
FT /note="Protein cramped-like"
FT /id="PRO_0000264472"
FT DOMAIN 158..221
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 1..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96RY5"
FT MOD_RES 1284
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96RY5"
FT CONFLICT 608
FT /note="A -> V (in Ref. 3; BAC98166)"
FT /evidence="ECO:0000305"
FT CONFLICT 650
FT /note="G -> D (in Ref. 3; BAC98166)"
FT /evidence="ECO:0000305"
FT CONFLICT 1174
FT /note="A -> T (in Ref. 3; BAC98166)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1285 AA; 137121 MW; DD331809EF6F6425 CRC64;
MTVKLGDAGS GEEGLKKLGK RTADEESLDG EGPGGADAAD SSSTKRDGQT PRASGAPAPP
RGLPTPSPPQ GSPQDQHHFL RSSVRPQSKR PRKDAPCALG SGGASGSGPR GKGSDGGASS
SGNVSGATPA TPAGGSRSSS RNIGSSGPEK EEGKKVRRQW ESWSTEDKNT FFEGLYEHGK
DFEAIQNNIA LKYKKKGKPA SMVKNKEQVR HFYYRTWHKI TKYIDFDNVF SRGLKKSSQE
LYGLICYGEL RKKIGGCMDD KNATKLNELI QVGATTVRYK GRNLRIKAPM CRALKKLCDP
DGLSDEEDQK PVRLPLKVPV ELQPRNNHAW ARVQSLAQNP RLRMIVELHR KVSSLIEFLK
QKWALHEVRI RKTLEERQLQ GSSTVQTQEK VALHLFPGEN CTLTPLPGVA RVVHSKAFCT
VHWQEGGRCK QGTKDIHSLP PAQILGIQSG QGIARGQLKC QRSSAEGKGG GRLLPTADAS
QSSGESSPES APAEGAAPSL SSPDAPDRPH GLQDSGPHLE KTPVTALAVG RDSPIQESGA
LPCPCGQPPD LEDELSLLDP FPRYLKSCQD LIIPEQCRRA DTRSGREHPP LGSVASPETL
TPSSGAVADS APPGLDPQPG TDHQPDTRLQ SDICTKELAN ASSEESQEKG SPSEHLSSQG
QPATRPSKEV PASQLAQQLR EEGWSLQTSE SLTLAEVYLM MGKPTKLQLE YDWLAVLGPE
SQAPTAQGQT ALSRSSPSAL HQQRLLSCLL RLISTEVHPK MAFEANTAST ASVRPTQEEQ
STTPPGKVVT INSRSPRCSR NPSTLRSNKT FPSASAPCSP GLRNPPRPLL VAGPSSTGSS
DSDGGLFAVP TTLPPNSRHG KLFSPSKEAE LTFRQHLDSI SIQSDFFSPK PKKLRKRHLR
KPLVVQRTLL PRPSENQSHN VCSFSILSNS PIAGRGWFRP IQSSLTKAAL SRPIVPKVLP
SQATSHLPSA IDLAAQSAGI IPGSPLPILD TDGSSGISPL SSEQATTAIS GQGDTGPHQN
RDPVTAVRGT NDPFISVTRP EQEPMTDGFQ GSPALTLPEL SKANLQNGLS IPLPSSESSS
TRLSPPNVSA LLDISLPGPP EDVLSQGEPA TQISDSIIEI AISSGQYSEG VPLSPAKLNG
SDSSKSLPSP SSSPQPNWIA SPTHDPQWYP SDSADSSLSS LFASFISPEK SRKMLPTTVG
ANSGTSLLGP SLLDGNSRDS FVSRSLADVA EVVDSQLVCM MNENSIDYIS RFNDLAQELS
ITEPGRREVL FDGGGGGNPV GDLSQ
