CRN6_CAEEL
ID CRN6_CAEEL Reviewed; 378 AA.
AC P34508; Q9NAQ0; Q9NCF8;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cell death-related nuclease 6;
DE EC=3.1.-.-;
DE Flags: Precursor;
GN Name=crn-6; ORFNames=K04H4.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND FUNCTION.
RX PubMed=12718884; DOI=10.1016/s1097-2765(03)00095-9;
RA Parrish J.Z., Xue D.;
RT "Functional genomic analysis of apoptotic DNA degradation in C. elegans.";
RL Mol. Cell 11:987-996(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 18-369 (ISOFORM A).
RX PubMed=10903447; DOI=10.1016/s0378-1119(00)00209-2;
RA Krieser R.J., Eastman A.;
RT "Deoxyribonuclease II: structure and chromosomal localization of the murine
RT gene, and comparison with the genomic structure of the human and three C.
RT elegans homologs.";
RL Gene 252:155-162(2000).
CC -!- FUNCTION: Involved in the degradation of chromosomal DNA. Contributes
CC to cell killing. {ECO:0000269|PubMed:12718884}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=P34508-1; Sequence=Displayed;
CC Name=a;
CC IsoId=P34508-2; Sequence=VSP_001304;
CC -!- SIMILARITY: Belongs to the DNase II family. {ECO:0000305}.
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DR EMBL; AY303580; AAP57302.1; -; mRNA.
DR EMBL; Z27078; CAA81586.2; -; Genomic_DNA.
DR EMBL; Z19153; CAA81586.2; JOINED; Genomic_DNA.
DR EMBL; Z27078; CAB76843.1; -; Genomic_DNA.
DR EMBL; AF220525; AAF43008.1; -; mRNA.
DR PIR; S40996; S40996.
DR RefSeq; NP_499061.2; NM_066660.4. [P34508-1]
DR RefSeq; NP_499062.1; NM_066661.1.
DR AlphaFoldDB; P34508; -.
DR SMR; P34508; -.
DR BioGRID; 41514; 3.
DR STRING; 6239.K04H4.6b.2; -.
DR EPD; P34508; -.
DR PaxDb; P34508; -.
DR PeptideAtlas; P34508; -.
DR EnsemblMetazoa; K04H4.6a.1; K04H4.6a.1; WBGene00000799. [P34508-2]
DR EnsemblMetazoa; K04H4.6b.1; K04H4.6b.1; WBGene00000799. [P34508-1]
DR GeneID; 176316; -.
DR KEGG; cel:CELE_K04H4.6; -.
DR UCSC; K04H4.6b; c. elegans. [P34508-1]
DR CTD; 176316; -.
DR WormBase; K04H4.6a; CE25043; WBGene00000799; crn-6. [P34508-2]
DR WormBase; K04H4.6b; CE31813; WBGene00000799; crn-6. [P34508-1]
DR eggNOG; KOG3825; Eukaryota.
DR GeneTree; ENSGT00390000002634; -.
DR InParanoid; P34508; -.
DR OMA; HMPQLCA; -.
DR OrthoDB; 605654at2759; -.
DR PhylomeDB; P34508; -.
DR BRENDA; 3.1.22.1; 1045.
DR PRO; PR:P34508; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000799; Expressed in embryo and 4 other tissues.
DR GO; GO:0004531; F:deoxyribonuclease II activity; IMP:WormBase.
DR GO; GO:0006309; P:apoptotic DNA fragmentation; IMP:WormBase.
DR GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IMP:WormBase.
DR InterPro; IPR004947; DNase_II.
DR PANTHER; PTHR10858; PTHR10858; 1.
DR Pfam; PF03265; DNase_II; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Glycoprotein; Hydrolase; Nuclease;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..378
FT /note="Cell death-related nuclease 6"
FT /id="PRO_0000007298"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 364..378
FT /note="ATLTVLLIAIITFFK -> VDALANNRYF (in isoform a)"
FT /evidence="ECO:0000303|PubMed:10903447,
FT ECO:0000303|PubMed:12718884"
FT /id="VSP_001304"
FT CONFLICT 40
FT /note="L -> F (in Ref. 4; AAF43008)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="S -> P (in Ref. 4; AAF43008)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 378 AA; 43348 MW; E84D6C8F80EEF8F9 CRC64;
MIRQIILIVS LIGISNAAYQ CKDNNGSNVD WFVFYKLPHL WNHPDNVPIS NGTGFLYFDV
NNKNWKLMPQ GMDVENNAVY YTLQQYYNSN MNTTFSYMYN DEWPDSTIWS NSSGHAKGVT
VFDQYTGFWM IHSIPKFPSK DMFRFPSNAH YYGQMGICIS YNTVSLATIA QQLFYYNTFT
YQFNLPQSFA NQFPVLSQLK NKEYNKSPPL TSTKVLKSLG GQHFRHFAKT GEWGKDLYSD
FVGPTLKSSI KVETWNHQSG DEYNLPSVCD PNHVQSTMSA KYIRLPYAID YSSYEDHSKF
VVAYSESSSK PPIPYVCIGD INRQSHQIHR GGGTMCIYDQ ETYFQFANII SETVPCTKAT
AEKATLTVLL IAIITFFK
