ID   CRNF_LYMST              Reviewed;         121 AA.
AC   P91758;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Cysteine-rich neurotrophic factor;
DE            Short=CRNF;
DE   Flags: Precursor;
OS   Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Lymnaeidae; Lymnaea.
OX   NCBI_TaxID=6523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=8929417; DOI=10.1126/science.274.5292.1540;
RA   Fainzilber M., Smit A.B., Syed N.I., Wildering W.C., Hermann P.M.,
RA   van der Schors R.C., Jimenez C., Li K.W., van Minnen J., Bulloch A.G.M.,
RA   Ibanez C.F., Geraerts W.P.M.;
RT   "CRNF, a molluscan neurotrophic factor that interacts with the p75
RT   neurotrophin receptor.";
RL   Science 274:1540-1543(1996).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Levy Z., Jaaro H., Conticello S.G., Fainzilber M.;
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with the p75 low-affinity neurotrophin receptor.
CC       Evokes neurite outgrowth and modulated calcium currents in pedal motor
CC       neurons. May be involved in target-derived trophic support for motor
CC       neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; U72990; AAC47397.2; -; mRNA.
DR   AlphaFoldDB; P91758; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Growth factor; Secreted; Signal.
FT   SIGNAL          1..18
FT   CHAIN           19..121
FT                   /note="Cysteine-rich neurotrophic factor"
FT                   /id="PRO_0000021004"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   121 AA;  13838 MW;  139B2F6EA7060E12 CRC64;
     MLLKLIVALS LTLTLASATS DPKGWFCSFE CNDWNQLEMA CQKEKDCFEK TNNQFTNETV
     ACMQPCWDLG IPCRTQCYKV YDQCTSDCPY TVPNPYECFT TCFKEAFAEV KPQIPKANLD
     E