CRNN_HUMAN
ID CRNN_HUMAN Reviewed; 495 AA.
AC Q9UBG3; B2RE60; Q8N613;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Cornulin;
DE AltName: Full=53 kDa putative calcium-binding protein;
DE AltName: Full=53 kDa squamous epithelial-induced stress protein;
DE AltName: Full=58 kDa heat shock protein;
DE AltName: Full=Squamous epithelial heat shock protein 53;
DE AltName: Full=Tumor-related protein;
GN Name=CRNN;
GN Synonyms=C1orf10 {ECO:0000303|PubMed:30009832}, DRC1, PDRC1,
GN SEP53 {ECO:0000303|PubMed:30009832};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal esophagus;
RX PubMed=11056050; DOI=10.1006/geno.2000.6344;
RA Xu Z., Wang M.-R., Xu X., Cai Y., Han Y.-L., Wu K.-M., Wang J., Chen B.-S.,
RA Wang X.-Q., Wu M.;
RT "Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure,
RT and frequent loss of expression in esophageal cancer.";
RL Genomics 69:322-330(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Esophagus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INDUCTION, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11606197; DOI=10.1046/j.0014-2956.2001.02468.x;
RA Yagui-Beltran A., Craig A.L., Lawrie L., Thompson D., Pospisilova S.,
RA Johnston D., Kernohan N., Hopwood D., Dillon J.F., Hupp T.R.;
RT "The human oesophageal squamous epithelium exhibits a novel type of heat
RT shock protein response.";
RL Eur. J. Biochem. 268:5343-5355(2001).
RN [7]
RP SUBUNIT, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=15896671; DOI=10.1016/j.biocel.2005.02.005;
RA Imai F.L., Uzawa K., Nimura Y., Moriya T., Imai M.A., Shiiba M., Bukawa H.,
RA Yokoe H., Tanzawa H.;
RT "Chromosome 1 open reading frame 10 (C1orf10) gene is frequently down-
RT regulated and inhibits cell proliferation in oral squamous cell
RT carcinoma.";
RL Int. J. Biochem. Cell Biol. 37:1641-1655(2005).
RN [8]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15854041; DOI=10.1111/j.0022-202x.2005.23694.x;
RA Contzler R., Favre B., Huber M., Hohl D.;
RT "Cornulin, a new member of the 'fused gene' family, is expressed during
RT epidermal differentiation.";
RL J. Invest. Dermatol. 124:990-997(2005).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=16466100; DOI=10.1177/000348940611500108;
RA Johnston N., Dettmar P.W., Lively M.O., Postma G.N., Belafsky P.C.,
RA Birchall M., Koufman J.A.;
RT "Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70)
RT response: role in laryngopharyngeal reflux disease.";
RL Ann. Otol. Rhinol. Laryngol. 115:47-58(2006).
RN [10]
RP INDUCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16640557; DOI=10.1111/j.1742-4658.2006.05206.x;
RA Darragh J., Hunter M., Pohler E., Nelson L., Dillon J.F., Nenutil R.,
RA Vojtesek B., Ross P.E., Kernohan N., Hupp T.R.;
RT "The calcium-binding domain of the stress protein SEP53 is required for
RT survival in response to deoxycholic acid-mediated injury.";
RL FEBS J. 273:1930-1947(2006).
RN [11]
RP TISSUE SPECIFICITY.
RX PubMed=17289885; DOI=10.1158/1078-0432.ccr-06-1577;
RA Luthra M.G., Ajani J.A., Izzo J., Ensor J., Wu T.T., Rashid A., Zhang L.,
RA Phan A., Fukami N., Luthra R.;
RT "Decreased expression of gene cluster at chromosome 1q21 defines molecular
RT subgroups of chemoradiotherapy response in esophageal cancers.";
RL Clin. Cancer Res. 13:912-919(2007).
RN [12]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND POSSIBLE INVOLVEMENT IN
RP PSORIASIS.
RX PubMed=30009832; DOI=10.1016/j.jid.2018.06.184;
RA Li C., Xiao L., Jia J., Li F., Wang X., Duan Q., Jing H., Yang P., Chen C.,
RA Wang Q., Liu J., Shao Y., Wang N., Zheng Y.;
RT "Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte
RT Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.";
RL J. Invest. Dermatol. 139:71-80(2019).
RN [13]
RP INVOLVEMENT IN ESCR, AND VARIANT ESCR SER-480.
RX PubMed=19558548; DOI=10.1111/j.1349-7006.2009.01240.x;
RA Zhang W., Chen X., Luo A., Lin D., Tan W., Liu Z.;
RT "Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma
RT in a Chinese population.";
RL Cancer Sci. 100:1695-1700(2009).
CC -!- FUNCTION: Promotes cell proliferation, G1/S cell cycle progression and
CC induces expression of the cell cycle regulator CCND1 (PubMed:30009832).
CC Regulates proliferation induced by pro-inflammatory cytokine response
CC via activation of NFKB1 and PI3K/AKT signaling pathways
CC (PubMed:30009832). {ECO:0000269|PubMed:30009832}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:15896671}.
CC -!- INTERACTION:
CC Q9UBG3; P61968: LMO4; NbExp=3; IntAct=EBI-3197866, EBI-2798728;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15854041,
CC ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1.
CC -!- TISSUE SPECIFICITY: Expressed in the basal skin layer (at protein
CC level) (PubMed:30009832). Squamous epithelia cell-specific. Expressed
CC in the esophagus (periphery of the cells of the granular and the upper
CC spinous layers), foreskin (granular and lower cornified cells), scalp
CC skin (granular layer), inner root sheath of the hair follicle and in
CC primary keratinocytes (at protein level). Expressed in the squamous
CC epithelium of the cervix, esophagus, foreskin and larynx. Expressed in
CC the fetal bladder and scalp skin. Expressed at very low levels in the
CC lung, kidney, uterus, skeletal muscle, heart and fetal brain.
CC Undetectable or barely detectable in esophageal and oral squamous cell
CC carcinoma compared with the matched adjacent normal esophageal mucosa.
CC Undetectable or barely detectable in larynx and esophagus from patients
CC with pH-documented laryngopharyngeal reflux (LPR).
CC {ECO:0000269|PubMed:11056050, ECO:0000269|PubMed:11606197,
CC ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:15896671,
CC ECO:0000269|PubMed:16466100, ECO:0000269|PubMed:16640557,
CC ECO:0000269|PubMed:17289885, ECO:0000269|PubMed:30009832}.
CC -!- INDUCTION: Up-regulated after heat shock, ponasterone A and deoxycholic
CC acid (PubMed:15896671, PubMed:16640557). Induced in response to pro-
CC inflammatory cytokines (PubMed:30009832). {ECO:0000269|PubMed:11606197,
CC ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16640557,
CC ECO:0000269|PubMed:30009832}.
CC -!- DOMAIN: The EF-hand is necessary for the colony survival activity to
CC protect cells from death induced by exposure to DCA.
CC -!- DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the
CC esophagus. The most common types are esophageal squamous cell carcinoma
CC and adenocarcinoma. Cancer of the esophagus remains a devastating
CC disease because it is usually not detected until it has progressed to
CC an advanced incurable stage. {ECO:0000269|PubMed:19558548}.
CC Note=Disease susceptibility is associated with variants affecting the
CC gene represented in this entry.
CC -!- DISEASE: Note=CRNN expression is increased in psoriasis patients
CC suggesting a potential role in disease pathogenesis.
CC {ECO:0000269|PubMed:30009832}.
CC -!- SIMILARITY: Belongs to the S100-fused protein family. {ECO:0000305}.
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DR EMBL; AF077831; AAD55747.1; -; mRNA.
DR EMBL; AF185276; AAF00514.1; -; Genomic_DNA.
DR EMBL; AK316568; BAG38157.1; -; mRNA.
DR EMBL; AL135842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW53381.1; -; Genomic_DNA.
DR EMBL; BC030807; AAH30807.1; -; mRNA.
DR CCDS; CCDS1010.1; -.
DR RefSeq; NP_057274.1; NM_016190.2.
DR AlphaFoldDB; Q9UBG3; -.
DR SMR; Q9UBG3; -.
DR BioGRID; 119069; 100.
DR IntAct; Q9UBG3; 22.
DR STRING; 9606.ENSP00000271835; -.
DR iPTMnet; Q9UBG3; -.
DR PhosphoSitePlus; Q9UBG3; -.
DR BioMuta; CRNN; -.
DR DMDM; 74761891; -.
DR EPD; Q9UBG3; -.
DR jPOST; Q9UBG3; -.
DR MassIVE; Q9UBG3; -.
DR PaxDb; Q9UBG3; -.
DR PeptideAtlas; Q9UBG3; -.
DR PRIDE; Q9UBG3; -.
DR ProteomicsDB; 83965; -.
DR Antibodypedia; 20343; 149 antibodies from 26 providers.
DR DNASU; 49860; -.
DR Ensembl; ENST00000271835.3; ENSP00000271835.3; ENSG00000143536.7.
DR GeneID; 49860; -.
DR KEGG; hsa:49860; -.
DR MANE-Select; ENST00000271835.3; ENSP00000271835.3; NM_016190.3; NP_057274.1.
DR UCSC; uc001ezx.3; human.
DR CTD; 49860; -.
DR DisGeNET; 49860; -.
DR GeneCards; CRNN; -.
DR HGNC; HGNC:1230; CRNN.
DR HPA; ENSG00000143536; Tissue enhanced (esophagus, vagina).
DR MalaCards; CRNN; -.
DR MIM; 133239; phenotype.
DR MIM; 611312; gene.
DR neXtProt; NX_Q9UBG3; -.
DR OpenTargets; ENSG00000143536; -.
DR PharmGKB; PA25601; -.
DR VEuPathDB; HostDB:ENSG00000143536; -.
DR eggNOG; ENOG502SATM; Eukaryota.
DR GeneTree; ENSGT00940000162465; -.
DR HOGENOM; CLU_043278_0_0_1; -.
DR InParanoid; Q9UBG3; -.
DR OMA; TNDQNRG; -.
DR OrthoDB; 1367189at2759; -.
DR PhylomeDB; Q9UBG3; -.
DR TreeFam; TF338665; -.
DR PathwayCommons; Q9UBG3; -.
DR SignaLink; Q9UBG3; -.
DR BioGRID-ORCS; 49860; 7 hits in 1058 CRISPR screens.
DR GenomeRNAi; 49860; -.
DR Pharos; Q9UBG3; Tbio.
DR PRO; PR:Q9UBG3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UBG3; protein.
DR Bgee; ENSG00000143536; Expressed in lower esophagus mucosa and 91 other tissues.
DR Genevisible; Q9UBG3; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IDA:UniProtKB.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IDA:UniProtKB.
DR GO; GO:1902808; P:positive regulation of cell cycle G1/S phase transition; IMP:UniProtKB.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IMP:UniProtKB.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; IMP:UniProtKB.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR026792; Cornulin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR11639:SF26; PTHR11639:SF26; 2.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 1: Evidence at protein level;
KW Calcium; Cytoplasm; Disease variant; Metal-binding; Reference proteome.
FT CHAIN 1..495
FT /note="Cornulin"
FT /id="PRO_0000305586"
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 96..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 68
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 73
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VARIANT 27
FT /note="A -> V (in dbSNP:rs35639220)"
FT /id="VAR_048469"
FT VARIANT 374
FT /note="Q -> H (in dbSNP:rs6695830)"
FT /id="VAR_048470"
FT VARIANT 480
FT /note="G -> S (in ESCR; dbSNP:rs3829868)"
FT /evidence="ECO:0000269|PubMed:19558548"
FT /id="VAR_048471"
SQ SEQUENCE 495 AA; 53533 MW; C4882A11B4E64DC3 CRC64;
MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL
LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG
TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS
PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ
TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ
TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ
DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST ESGRQEWSST
HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG
ITARELYSYL RSTKP
