ID   CROC4_HUMAN             Reviewed;         156 AA.
AC   Q13536; B1ALL5; B1ALL8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Protein CROC-4;
DE   AltName: Full=Contingent replication of cDNA 4;
DE   AltName: Full=MIR9-1 host gene {ECO:0000312|HGNC:HGNC:30780};
GN   Name=MIR9-1HG {ECO:0000312|HGNC:HGNC:30780};
GN   Synonyms=C1orf61 {ECO:0000312|HGNC:HGNC:30780}, CROC4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=10995546; DOI=10.1006/mcne.2000.0866;
RA   Jeffrey P.L., Capes-Davis A., Dunn J.M., Tolhurst O., Seeto G.,
RA   Hannan A.J., Lin S.L.;
RT   "CROC-4: a novel brain specific transcriptional activator of c-fos
RT   expressed from proliferation through to maturation of multiple neuronal
RT   cell types.";
RL   Mol. Cell. Neurosci. 16:185-196(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in FOS signaling pathways involved in
CC       development and remodeling of neurons. Promotes transcription of the
CC       FOS promoter. {ECO:0000269|PubMed:10995546}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10995546}.
CC       Note=Associates within the nuclear transcriptional apparatus during
CC       proliferation and differentiation.
CC   -!- TISSUE SPECIFICITY: Expressed throughout the brain in the thalamus,
CC       subthalamic nucleus, corpus callosum, hippocampus, substantia nigra,
CC       caudate nucleus, and amygdala. {ECO:0000269|PubMed:10995546}.
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DR   EMBL; U49857; AAA93029.1; -; mRNA.
DR   EMBL; AL139130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471121; EAW52956.1; -; Genomic_DNA.
DR   RefSeq; NP_006356.1; NM_006365.2.
DR   RefSeq; XP_011507372.1; XM_011509070.1.
DR   RefSeq; XP_011507373.1; XM_011509071.2.
DR   RefSeq; XP_011507374.1; XM_011509072.1.
DR   RefSeq; XP_016855551.1; XM_017000062.1.
DR   RefSeq; XP_016855552.1; XM_017000063.1.
DR   AlphaFoldDB; Q13536; -.
DR   BioGRID; 115748; 6.
DR   BioMuta; C1orf61; -.
DR   PaxDb; Q13536; -.
DR   PRIDE; Q13536; -.
DR   DNASU; 10485; -.
DR   GeneID; 10485; -.
DR   UCSC; uc001fou.2; human.
DR   CTD; 10485; -.
DR   DisGeNET; 10485; -.
DR   GeneCards; MIR9-1HG; -.
DR   HGNC; HGNC:30780; MIR9-1HG.
DR   MIM; 618747; gene.
DR   neXtProt; NX_Q13536; -.
DR   eggNOG; ENOG502TF2T; Eukaryota.
DR   HOGENOM; CLU_131272_0_0_1; -.
DR   InParanoid; Q13536; -.
DR   OrthoDB; 1271587at2759; -.
DR   PhylomeDB; Q13536; -.
DR   TreeFam; TF342418; -.
DR   PathwayCommons; Q13536; -.
DR   SignaLink; Q13536; -.
DR   SIGNOR; Q13536; -.
DR   BioGRID-ORCS; 10485; 8 hits in 1059 CRISPR screens.
DR   ChiTaRS; C1orf61; human.
DR   GenomeRNAi; 10485; -.
DR   Pharos; Q13536; Tdark.
DR   PRO; PR:Q13536; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q13536; protein.
DR   Genevisible; Q13536; HS.
DR   GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..156
FT                   /note="Protein CROC-4"
FT                   /id="PRO_0000333952"
FT   REGION          46..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   156 AA;  17231 MW;  939C3E7168FE35CE CRC64;
     MFLTEDLITF NLRNFLLFQL WESSFSPGAG GFCTTLPPSF LRVDDRATSS TTDSSRAPSS
     PRPPGSTSHC GISTRCTERC LCVLPLRTSQ VPDVMAPQHD QEKFHDLAYS CLGKSFSMSN
     QDLYGYSTSS LALGLAWLSW ETKKKNVLHL VGLDSL