CROL2_HUMAN
ID CROL2_HUMAN Reviewed; 287 AA.
AC Q8IVE0; Q96PW6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Putative ciliary rootlet coiled-coil protein-like 2 protein;
DE AltName: Full=Ciliary rootlet coiled-coil protein pseudogene 3;
GN Name=CROCCP3; Synonyms=CROCCL2, KIAA1922;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the rootletin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB67815.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB067509; BAB67815.1; ALT_INIT; mRNA.
DR EMBL; AL137802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471167; EAW51787.1; -; Genomic_DNA.
DR EMBL; BC033082; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q8IVE0; -.
DR SMR; Q8IVE0; -.
DR iPTMnet; Q8IVE0; -.
DR PhosphoSitePlus; Q8IVE0; -.
DR BioMuta; HGNC:29405; -.
DR DMDM; 74728061; -.
DR jPOST; Q8IVE0; -.
DR MassIVE; Q8IVE0; -.
DR MaxQB; Q8IVE0; -.
DR PeptideAtlas; Q8IVE0; -.
DR PRIDE; Q8IVE0; -.
DR ProteomicsDB; 70682; -.
DR GeneCards; CROCCP3; -.
DR HGNC; HGNC:29405; CROCCP3.
DR neXtProt; NX_Q8IVE0; -.
DR InParanoid; Q8IVE0; -.
DR PhylomeDB; Q8IVE0; -.
DR ChiTaRS; CROCCP3; human.
DR Pharos; Q8IVE0; Tdark.
DR PRO; PR:Q8IVE0; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8IVE0; protein.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0035253; C:ciliary rootlet; IEA:InterPro.
DR GO; GO:0007098; P:centrosome cycle; IBA:GO_Central.
DR InterPro; IPR026733; Rootletin.
DR PANTHER; PTHR23159:SF17; PTHR23159:SF17; 2.
PE 5: Uncertain;
KW Coiled coil; Reference proteome.
FT CHAIN 1..287
FT /note="Putative ciliary rootlet coiled-coil protein-like 2
FT protein"
FT /id="PRO_0000309213"
FT REGION 176..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..179
FT /evidence="ECO:0000255"
FT COMPBIAS 221..243
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 33334 MW; FDCF64E64D165992 CRC64;
MRGRYEASQD LLGTLRKQLS DSESERRALE EQLQRLRDKT DSTMQAHEDA QREVQRLRSA
KELLRREKSN LAHSLQVAQQ QAKELRQERK KLQAAQEELR RQRYWLGEEQ EDAVQDGVRV
RRELERSHRQ LEQLEGKRSV LAKELVEVRE ALSRATLQRD MLQAEKAEVA EALTKAEGRG
GLPAGLPVQA ERPQREPCSG QVGSEPPCHP GHSWRKKSAP CRAGSGRRSR RPQWHGKSRS
GWRRCGWNRR WRGRAWRAPY ERRSRPRRQW SSSSPRCIMS AAGCRSS
