ID   CROM_ENTDO              Reviewed;         496 AA.
AC   P30841;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Omega-crystallin;
OS   Enteroctopus dofleini (North Pacific giant octopus) (Octopus dofleini).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Enteroctopus.
OX   NCBI_TaxID=267067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7684383; DOI=10.1016/s0021-9258(18)82144-5;
RA   Zinovieva R.D., Tomarev S.I., Piatigorsky J.;
RT   "Aldehyde dehydrogenase-derived omega-crystallins of squid and octopus.
RT   Specialization for lens expression.";
RL   J. Biol. Chem. 268:11449-11455(1993).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RX   PubMed=1721068; DOI=10.1016/s0021-9258(18)54416-1;
RA   Tomarev S.I., Zinovieva R.D., Piatigorsky J.;
RT   "Crystallins of the octopus lens. Recruitment from detoxification
RT   enzymes.";
RL   J. Biol. Chem. 266:24226-24231(1991).
CC   -!- FUNCTION: Omega-crystallins are structural components of squids and
CC       octopi eye lens. Contains relatively little if any DHAL activity.
CC   -!- TISSUE SPECIFICITY: Lens.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; L06902; AAA29392.1; -; Genomic_DNA.
DR   PIR; A46725; A46725.
DR   AlphaFoldDB; P30841; -.
DR   SMR; P30841; -.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Eye lens protein.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..496
FT                   /note="Omega-crystallin"
FT                   /id="PRO_0000056601"
FT   VARIANT         303
FT                   /note="A -> I"
FT   VARIANT         382
FT                   /note="F -> I"
SQ   SEQUENCE   496 AA;  55493 MW;  2D3D8D6FCCCD4765 CRC64;
     MAGLPPPNKT PEIKFTKIFI NNQFVDSVNG KAYSVINPCT TKKICDVQEG SKADIDKAVQ
     ACKLAFKRGT PWRRMDASRR GHLLYRLADL FERDIAYLSS LETLNTGKPY KSAYQDIVHC
     IQVLRYYAGW ADKNMGQNIP VDGDFFSFTK HEPVGICGLI IPWNYPMLMM TWKMAPALSC
     GNCIVVKPAE QTPLTALYCA SLMEEAGFPP GVVNVVPGYG TICGQSISSH LDINKVSFTG
     STEVGKLVMQ AAGSSNLKRC SLELSGKCPV VVFPDTDLDF AVQQAHEAAF QNMGQCRWSG
     SRAYVHESIY EEFVKRSVEQ ATRRKIGDPY ELDTEHGPQI DEEQYTKVLD YIKSAQEQGA
     KLKYGGNKHG DKGGYYIEPT VFSEVSDNMK IAKEEIFGPV QLLMKFRDLD DVIDRCNNSD
     YGMAAAIFTN DINRIMTFTN AVNTGTIWVN TFHHWFPQAP FGGFKTSGIS REMGKYALRE
     YTEVKSVIYR IPQKDS